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Low-dose ionizing radiation modulates the expression of proangiogenic genes in critical limb ischemia patients : preliminary results

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Objective: Low-dose ionizing radiation (LDIR), namely, 0.3 Gy, delivered during 4 consecutive days, has been reported to stimulate angiogenesis and arteriogenesis in a preclinical model of hindlimb ischemia. Here we performed a single-center, investigator-blinded, randomized, shamcontrolled clinical trial to evaluate the effects of LDIR exposure in the expression of proangiogenic genes in endothelial cells isolated from muscles of patients with critical limb ischemia.

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© 2019 Published by Elsevier Inc.

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Journal of Vascular Surgery, Volume 70, Issue 5, e122 - e123

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Elsevier

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