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Immunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinoma

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dc.contributor.authorVala, Helena
dc.contributor.authorCarvalho, Tânia
dc.contributor.authorPinto, Carlos
dc.contributor.authorPereira, Maria A.
dc.contributor.authorMesquita, João R.
dc.contributor.authorPeleteiro, Maria C.
dc.contributor.authorFerrer, Lluís
dc.contributor.authorFondevila, Dolores
dc.date.accessioned2022-01-21T12:26:45Z
dc.date.available2022-01-21T12:26:45Z
dc.date.issued2020
dc.description© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractBovine Ocular Squamous Cell Carcinoma is considered the most common bovine tumour, causing significant economic losses, mainly by abattoir condemnations. To obtain a better insight into the genesis and neoplastic transformation, 19 samples collected at slaughter from Holstein Friesian cattle and diagnosed as Ocular Squamous Cell Carcinoma were studied. Tumours were histologically classified into three categories: poorly (26.3%), moderately (26.3%), and well differentiated (47.4%). Expression of keratins (MNF116 and LP34) and of cornified envelope precursors (involucrin and profilaggrin) was studied. Expression of MNF116 was observed in all carcinomas. LP34 immunostaining was seen in all but three carcinomas, one from each degree. Involucrin immunoreaction was observed in all but one poorly differentiated carcinoma. Profilaggrin was present in only two moderately differentiated carcinomas, in all but one well differentiated, and in all but one poorly differentiated. MNF116 is a useful marker to confirm the epithelial origin of the tumour and stain most neoplastic cells in these tumours. The expression of involucrin and LP34 demonstrates that, in all tumours, cells have reached the final program of differentiation, regardless of the grade. The expression of profilaggrin could indicate molecular changes during malignant transformation but their expression does not seem to be of diagnostic value.pt_PT
dc.description.sponsorshipThis research was funded by Interdisciplinary Investigation Centre for Animal Health (CIISA) from the Faculty of Veterinary Medicine, Lisbon, and by Portuguese Foundation for Science and Technology (FCT) under the project UIDB/04033/2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVet Sci. 2020 May 29;7(2):70pt_PT
dc.identifier.doi10.3390/vetsci7020070pt_PT
dc.identifier.eissn2306-7381
dc.identifier.urihttp://hdl.handle.net/10451/50910
dc.language.isospapt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relation.publisherversionhttps://www.mdpi.com/journal/vetscipt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBovinept_PT
dc.subjectCytokeratinpt_PT
dc.subjectImmunohistochemistrypt_PT
dc.subjectInvolucrinpt_PT
dc.subjectOcular squamous cell carcinomapt_PT
dc.subjectProfilaggrinpt_PT
dc.titleImmunohistochemical studies of cytokeratins and differentiation markers in bovine ocular squamous cell carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.citation.issue2pt_PT
oaire.citation.titleVeterinary Sciencespt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCarvalho
person.familyNamePeleteiro
person.givenNameTânia
person.givenNameMaria
person.identifier.ciencia-id4C10-5743-02F8
person.identifier.orcid0000-0002-5283-5013
person.identifier.orcid0000-0003-1848-558X
person.identifier.ridJ-3656-2013
person.identifier.scopus-author-id25653983600
person.identifier.scopus-author-id6602767105
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf5654a66-bbe2-49fa-bd86-a3d9207cb592
relation.isAuthorOfPublicationf78bed14-16c3-4f65-b27c-93a490d55ce1
relation.isAuthorOfPublication.latestForDiscoveryf78bed14-16c3-4f65-b27c-93a490d55ce1
relation.isProjectOfPublication7a6510b5-ce03-44ea-88c5-007d0ab7329c
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