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Dairy intake and Parkinson's disease: a Mendelian randomization study

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dc.contributor.authorDomenighetti, Cloé
dc.contributor.authorSugier, Pierre‐Emmanuel
dc.contributor.authorAshok Kumar Sreelatha, Ashwin
dc.contributor.authorSchulte, Claudia
dc.contributor.authorGrover, Sandeep
dc.contributor.authorMohamed, Océane
dc.contributor.authorPortugal, Berta
dc.contributor.authorMay, Patrick
dc.contributor.authorBobbili, Dheeraj R.
dc.contributor.authorRadivojkov‐Blagojevic, Milena
dc.contributor.authorLichtner, Peter
dc.contributor.authorSingleton, Andrew B.
dc.contributor.authorHernandez, Dena G.
dc.contributor.authorEdsall, Connor
dc.contributor.authorMellick, George D.
dc.contributor.authorZimprich, Alexander
dc.contributor.authorPirker, Walter
dc.contributor.authorRogaeva, Ekaterina
dc.contributor.authorLang, Anthony E.
dc.contributor.authorKoks, Sulev
dc.contributor.authorTaba, Pille
dc.contributor.authorLesage, Suzanne
dc.contributor.authorBrice, Alexis
dc.contributor.authorCorvol, Jean‐Christophe
dc.contributor.authorChartier‐Harlin, Marie‐Christine
dc.contributor.authorMutez, Eugénie
dc.contributor.authorBrockmann, Kathrin
dc.contributor.authorDeutschländer, Angela B.
dc.contributor.authorHadjigeorgiou, Georges M.
dc.contributor.authorDardiotis, Efthimos
dc.contributor.authorStefanis, Leonidas
dc.contributor.authorSimitsi, Athina Maria
dc.contributor.authorValente, Enza Maria
dc.contributor.authorPetrucci, Simona
dc.contributor.authorDuga, Stefano
dc.contributor.authorStraniero, Letizia
dc.contributor.authorZecchinelli, Anna
dc.contributor.authorPezzoli, Gianni
dc.contributor.authorBrighina, Laura
dc.contributor.authorFerrarese, Carlo
dc.contributor.authorAnnesi, Grazia
dc.contributor.authorQuattrone, Andrea
dc.contributor.authorGagliardi, Monica
dc.contributor.authorMatsuo, Hirotaka
dc.contributor.authorKawamura, Yusuke
dc.contributor.authorHattori, Nobutaka
dc.contributor.authorNishioka, Kenya
dc.contributor.authorChung, Sun Ju
dc.contributor.authorKim, Yun Joong
dc.contributor.authorKolber, Pierre
dc.contributor.authorWarrenburg, Bart P.C.
dc.contributor.authorBloem, Bastiaan R.
dc.contributor.authorAasly, Jan
dc.contributor.authorToft, Mathias
dc.contributor.authorPihlstrøm, Lasse
dc.contributor.authorCorreia Guedes, Leonor
dc.contributor.authorFerreira, Joaquim J
dc.contributor.authorBardien, Soraya
dc.contributor.authorCarr, Jonathan
dc.contributor.authorTolosa, Eduardo
dc.contributor.authorEzquerra, Mario
dc.contributor.authorPastor, Pau
dc.contributor.authorDiez‐Fairen, Monica
dc.contributor.authorWirdefeldt, Karin
dc.contributor.authorPedersen, Nancy L.
dc.contributor.authorRan, Caroline
dc.contributor.authorBelin, Andrea C.
dc.contributor.authorPuschmann, Andreas
dc.contributor.authorHellberg, Clara
dc.contributor.authorClarke, Carl E.
dc.contributor.authorMorrison, Karen E.
dc.contributor.authorTan, Manuela
dc.contributor.authorKrainc, Dimitri
dc.contributor.authorBurbulla, Lena F.
dc.contributor.authorFarrer, Matt J.
dc.contributor.authorKrüger, Rejko
dc.contributor.authorGasser, Thomas
dc.contributor.authorSharma, Manu
dc.contributor.authorElbaz, Alexis
dc.date.accessioned2022-02-02T15:58:59Z
dc.date.available2022-02-02T15:58:59Z
dc.date.issued2022
dc.description© 2022 International Parkinson and Movement Disorder Societypt_PT
dc.description.abstractBackground: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029). Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.pt_PT
dc.description.sponsorshipThis study used data from the Courage-PD consortium, conducted under a partnership agreement among 35 studies. The Courage-PD consortium is supported by the EU Joint Program for Neurodegenerative Disease research (JPND; https://www.neurodegenerationresearch.eu/initiatives/annual-calls-for-proposals/closed-calls/risk-factors-2012/risk-factor-call-results/courage-pd/). C.D. is the recipient of a doctoral grant from Université Paris-Saclay, France. P.M. was funded by the Fonds National de Recherche (FNR), Luxembourg, as part of the National Centre of Excellence in Research on Parkinson's Disease (NCER-PD, FNR11264123) and the DFG Research Units FOR2715 (INTER/DFG/17/11583046) and FOR2488 (INTER/DFG/19/14429377). A.B.S., D.G.H., and C.E. are funded by the Intramural Research Program of the National Institute on Aging, National Institutes of Health, Department of Health and Human Services, project ZO1 AG000949. E.R. is funded by the Canadian Consortium on Neurodegeneration in Aging. S.K. is funded by MSWA. P.T. is the recipient of an Estonian Research Council Grant PRG957. E.M.V. is funded by the Italian Ministry of Health (Ricerca Corrente 2021). S.B. and J.C. are supported by grants from the National Research Foundation of South Africa (grant number: 106052); the South African Medical Research Council (Self-Initiated Research Grant); and Stellenbosch University, South Africa; they also acknowledge the support of the NRF-DST Centre of Excellence for Biomedical Tuberculosis Research; South African Medical Research Council Centre for Tuberculosis Research; and Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town. P.P. and M.D.-F. have received funding from the Spanish Ministry of Science and Innovation (SAF2013-47939-R). K.W. and N.L.P. are funded by the Swedish Research Council, grant numbers K2002-27X-14056-02B, 521-2010-2479, 521-2013-2488, and 2017-02175. N.L.P. is funded by the National Institutes of Health, grant numbers ES10758 and AG 08724. C.R. is funded by the Märta Lundkvist Foundation, Swedish Brain Foundation, and Karolinska Institutet Research Fund. A.C.B. is funded by the Swedish Brain Foundation, Swedish Research Council, and Karolinska Institutet Research Funds. M.T. (M. Tan) is funded by the Parkinson's UK. M.S. was supported by grants from the German Research Council (DFG/SH 599/6-1), MSA Coalition, and The Michael J. Fox Foundation (USA Genetic Diversity in PD Program: GAP-India Grant ID: 17473). PG GEN sample collection was funded by the MRC and UK Medical Research Council (C.E.C. and K.E.M.).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMov Disord. 2022 Jan 8pt_PT
dc.identifier.doi10.1002/mds.28902pt_PT
dc.identifier.eissn1531-8257
dc.identifier.issn0885-3185
dc.identifier.urihttp://hdl.handle.net/10451/51089
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://movementdisorders.onlinelibrary.wiley.com/journal/15318257pt_PT
dc.subjectDairy intakept_PT
dc.subjectParkinson's diseasept_PT
dc.subjectMendelian randomizationpt_PT
dc.titleDairy intake and Parkinson's disease: a Mendelian randomization studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMovement Disorderspt_PT
person.familyNameCorreia Guedes
person.familyNameFerreira
person.givenNameLeonor
person.givenNameJoaquim J
person.identifier1624753
person.identifier.ciencia-id1518-348B-19BD
person.identifier.ciencia-id7D15-5CD6-6159
person.identifier.orcid0000-0002-8422-0494
person.identifier.orcid0000-0003-3950-5113
person.identifier.scopus-author-id7403252466
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc67bea09-55ea-4363-804e-0b8cb194da4a
relation.isAuthorOfPublication54d84fe7-2cbd-4ddc-bce2-0ff2bd7c4cc9
relation.isAuthorOfPublication.latestForDiscovery54d84fe7-2cbd-4ddc-bce2-0ff2bd7c4cc9

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