Publicação
Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
| dc.contributor.author | Quiroz, César | |
| dc.contributor.author | Gomes, Catarina | |
| dc.contributor.author | Pak, Arlene C. | |
| dc.contributor.author | Ribeiro, Joaquim A. | |
| dc.contributor.author | Goldberg, Steven R. | |
| dc.contributor.author | Hope, Bruce T. | |
| dc.contributor.author | Ferré, Sergi | |
| dc.date.accessioned | 2013-04-03T10:34:59Z | |
| dc.date.available | 2013-04-03T10:34:59Z | |
| dc.date.issued | 2006 | |
| dc.description | ©2006 Society for Neuroscience | por |
| dc.description.abstract | Previous studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons. In the present study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A receptor antagonist counteracts the striatal activation of cAMP– protein kinase A cascade (phosphorylation of the Ser845 residue of the glutamate receptor 1 subunit of the AMPA receptor) and mitogenactivated protein kinase (ERK1/2 phosphorylation) induced by the in vivo stimulation of corticostriatal afferents. The results indicate that A2A receptors strongly modulate the efficacy of glutamatergic synapses on striatal enkephalinergic neurons. | eng |
| dc.description.sponsorship | This work was supported by the Intramural Research Program of the National Institutes of Health, National Institute on Drug Abuse, Department of Health and Human Services. | eng |
| dc.identifier.citation | The Journal of Neuroscience, October 18, 2006 • 26(42):10808 –10812 | eng |
| dc.identifier.issn | 0270-6474 | |
| dc.identifier.uri | http://dx.doi.org/10.1523/JNEUROSCI.1661-06.2006 | |
| dc.identifier.uri | http://hdl.handle.net/10451/8188 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Society for Neuroscience | eng |
| dc.subject | Caffeine | eng |
| dc.subject | Adenosine A2A receptor | eng |
| dc.subject | Striatum | eng |
| dc.subject | Phosphorylation | eng |
| dc.subject | ERK1/2 | eng |
| dc.subject | AMPA receptor | eng |
| dc.title | Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 10812 | por |
| oaire.citation.startPage | 10808 | por |
| oaire.citation.title | The Journal of Neuroscience | eng |
| oaire.citation.volume | 26 | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |