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Publicação
Blockade of adenosine A2A receptors prevents protein phosphorylation in the striatum induced by cortical stimulation
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Orientador(es)
Resumo(s)
Previous studies have shown that cortical stimulation selectively activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation and immediate early gene expression in striatal GABAergic enkephalinergic neurons. In the present study, we demonstrate that blockade of adenosine A2A receptors with caffeine or a selective A2A receptor antagonist counteracts the striatal activation of cAMP–
protein kinase A cascade (phosphorylation of the Ser845 residue of the glutamate receptor 1 subunit of the AMPA receptor) and mitogenactivated protein kinase (ERK1/2 phosphorylation) induced by the in vivo stimulation of corticostriatal afferents. The results indicate that A2A receptors strongly modulate the efficacy of glutamatergic synapses on striatal enkephalinergic neurons.
Descrição
©2006 Society for Neuroscience
Palavras-chave
Caffeine Adenosine A2A receptor Striatum Phosphorylation ERK1/2 AMPA receptor
Contexto Educativo
Citação
The Journal of Neuroscience, October 18, 2006 • 26(42):10808 –10812
Editora
Society for Neuroscience