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HPV como co-factor da carcinogénese do pulmão
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Resumo(s)
O cancro do pulmão é a principal causa de morte por cancro no mundo. No entanto, a epidemiologia dos diversos tipos de neoplasias do pulmão é extremamente heterogénea. A existência de diferentes cofatores, em particular ambientais, tais como a nutrição, o tabagismo, o microbioma e o viroma, podem explicar algumas destas discrepâncias. A incidência do cancro do pulmão e a sua mortalidade justificam a pesquisa de cofatores de carcinogénese que possam vir a ter impacto terapêutico ou prognóstico. Alguns agentes ambientais são bem conhecidos como carcinogénicos na história natural de diversas neoplasias, sendo o Vírus do Papiloma Humano um exemplo hegemónico. Trabalhos recentes sugerem que o HPV pode ter um papel independente na carcinogénese do pulmão, alterando vias de desenvolvimento, expressão de marcadores tumorais, resposta terapêutica e, em última instância, prognóstico. O propósito deste trabalho é apresentar uma revisão da literatura atual relativamente ao papel do viroma na patogénese do cancro do pulmão, focando a participação do HPV.
Lung cancer is the leading cause of cancer death in the world. However, the epidemiology of various types of lung malignancies is extremely diverse. The existence of distinct co-factors, such as nutrition, smoking, the microbiome and the virome, might explain these discrepancies. The association between the incidence of lung cancer and its mortality justifies the study and search of co-factors of carcinogenesis that might be impactful on therapeutics and prognosis. Some environmental agents are well-known for their roles in the natural history of many different malignancies, with Human Papilloma Virus being a prime example. Recent data suggests that HPV may have an independent role in lung cell carcinogenesis, potentially altering development pathways, tumor marker expression, therapeutic response and, ultimately, prognosis. The aim of this work is to present an updated literature review on the role of the virome on lung cancer pathogenesis, with particular focus on HPV participation.
Lung cancer is the leading cause of cancer death in the world. However, the epidemiology of various types of lung malignancies is extremely diverse. The existence of distinct co-factors, such as nutrition, smoking, the microbiome and the virome, might explain these discrepancies. The association between the incidence of lung cancer and its mortality justifies the study and search of co-factors of carcinogenesis that might be impactful on therapeutics and prognosis. Some environmental agents are well-known for their roles in the natural history of many different malignancies, with Human Papilloma Virus being a prime example. Recent data suggests that HPV may have an independent role in lung cell carcinogenesis, potentially altering development pathways, tumor marker expression, therapeutic response and, ultimately, prognosis. The aim of this work is to present an updated literature review on the role of the virome on lung cancer pathogenesis, with particular focus on HPV participation.
Descrição
Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2022
Palavras-chave
Cancro do pulmão Viroma Vírus do papiloma humano (VPH)