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Vascular function after acute aerobic exercise in adults with and without type 2 diabetes mellitus

2025Journal article Open access
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dc.contributor.authorMarôco, João Luís
dc.contributor.authorArrais, Inês
dc.contributor.authorSilvestre, Tiago
dc.contributor.authorPinto, Marco
dc.contributor.authorLaranjo, Sergio
dc.contributor.authorMagalhães, João P.
dc.contributor.authorSanta-Clara, Helena
dc.contributor.authorFernhall, Bo
dc.contributor.authorMelo, Xavier
dc.date.accessioned2025-07-30T10:54:21Z
dc.date.available2025-07-30T10:54:21Z
dc.date.issued2025
dc.description© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.pt_PT
dc.description.abstractIt is unknown whether type 2 diabetes mellitus (T2DM) influences the vascular function response to aerobic exercise. We examined brachial artery flow-mediated dilation (FMD) and flow-mediated slowing (FMS) of pulse wave velocity (PWV), 10-and 60-min after a high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) in adults with and without T2DM. Twelve older male adults with T2DM (57-84 years), and twenty-four healthy young and older adults (12 per group, aged 20-40 years and 57-76 years, respectively), completed an acute bout of HIIE, MICE, and a non-exercise condition. FMD was evaluated by the same researcher following standardized guidelines. FMS was calculated from the manufacturer's PWV beta formulas. Central arterial stiffness was estimated via carotid-femoral PWV (cfPWV). %FMD was reduced (d= - 5.94%, 95% CI: - 10.50 to - 1.38%, p = 0.002), whereas %FMS increased (d = 4.55%, 95% CI: 0.62 to 8.48%, p = 0.01), 10-min after HIIE only in adults with T2DM, normalizing 60-min into recovery. Conversely, %FMD was increased (d = 5.33%, 95% CI: 0.76 to 9.89%, p = 0.009) 10-min after MICE only in adults with T2DM. cfPWV remained unchanged following HIIE and MICE in all groups. We report disease-associated vascular function responses to aerobic exercise suggesting both HIIE and MICE uncover transient vascular alterations in older adults with T2DM.pt_PT
dc.description.sponsorshipThe authors thank the Foundation for Science and Technology (FCT)/Portuguese Ministry of Science, Technology, and Higher Education (MCTES) for the financial support to CiiEM (10.54499/UIDB/04585/2020) through national funds. CiiEM has provided support through Project 10.54499/UIDB/04585/2020, funded by FCT.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSci Rep. 2025 Jul 16;15(1):25727pt_PT
dc.identifier.doi10.1038/s41598-025-10865-7pt_PT
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.5/102535
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.nature.com/srep/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.titleVascular function after acute aerobic exercise in adults with and without type 2 diabetes mellituspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F04585%2F2020/PT
oaire.citation.issue1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume15pt_PT
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
person.familyNameLaranjo
person.familyNameMagalhães
person.familyNameSanta-Clara
person.familyNameMelo
person.givenNameSergio
person.givenNameJoão Pedro
person.givenNameHelena
person.givenNameXavier
person.identifier36332
person.identifier1272667
person.identifier.ciencia-id351B-92E1-0C50
person.identifier.ciencia-idF61D-91AE-A33C
person.identifier.ciencia-idCE1C-5AB1-14B9
person.identifier.ciencia-idD010-C9C5-5147
person.identifier.orcid0000-0003-2169-4024
person.identifier.orcid0000-0003-1073-8650
person.identifier.orcid0000-0003-3134-3893
person.identifier.orcid0000-0003-3934-3986
person.identifier.ridG-2909-2011
person.identifier.ridIQW-2251-2023
person.identifier.ridG-7713-2016
person.identifier.scopus-author-id24391148400
person.identifier.scopus-author-id6506107238
person.identifier.scopus-author-id36613303700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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