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GDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptors

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dc.contributor.authorGomes, Catarina
dc.contributor.authorSimões, Patrícia F.
dc.contributor.authorCanas, Paula M.
dc.contributor.authorQuiroz, César
dc.contributor.authorSebastião, Ana M
dc.contributor.authorFerré, Sergi
dc.contributor.authorCunha, Rodrigo A.
dc.contributor.authorRibeiro, Joaquim A.
dc.date.accessioned2022-12-15T12:13:50Z
dc.date.available2022-12-15T12:13:50Z
dc.date.issued2009
dc.description© 2009 The Authors. Journal Compilation © 2009 International Society for Neurochemistrypt_PT
dc.description.abstractGlial cell line-derived neurotrophic factor (GDNF) affords neuroprotection in Parkinson's disease in accordance with its ability to bolster nigrostriatal innervation. We previously found that GDNF facilitates dopamine release in a manner dependent on adenosine A(2A) receptor activation. As motor dysfunction also involves modifications of striatal glutamatergic innervation, we now tested if GDNF and its receptor system, Ret (rearranged during transfection) and GDNF family receptor alpha1 controlled the cortico-striatal glutamatergic pathway in an A(2A) receptor-dependent manner. GDNF (10 ng/mL) enhanced (by approximately 13%) glutamate release from rat striatal nerve endings, an effect potentiated (up to approximately 30%) by the A(2A) receptor agonist CGS 21680 (10 nM) and prevented by the A(2A) receptor antagonist, SCH 58261 (50 nM). Triple immunocytochemical studies revealed that Ret and GDNF family receptor alpha1 were located in 50% of rat striatal glutamatergic terminals (immunopositive for vesicular glutamate transporters-1/2), where they were found to be co-located with A(2A) receptors. Activation of the glutamatergic system upon in vivo electrical stimulation of the rat cortico-striatal input induced striatal Ret phosphorylation that was prevented by pre-treatment with the A(2A) receptor antagonist, MSX-3 (3 mg/kg). The results provide the first functional and morphological evidence that GDNF controls cortico-striatal glutamatergic pathways in a manner largely dependent on the co-activation of adenosine A(2A) receptors.pt_PT
dc.description.sponsorshipThis study was supported by Fundação para a Ciência e para a Tecnologia, Portugal (work at Lisboa and Coimbra) and by the Intramural Research funds of the National Institute on Drug Abuse, NIH, USA and Faculdade de Medicina, Universidade de Lisboa, Portugal.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Neurochem. 2009 Mar;108(5):1208-1219pt_PT
dc.identifier.doi10.1111/j.1471-4159.2009.05876.xpt_PT
dc.identifier.eissn1471-4159
dc.identifier.issn0022-3042
dc.identifier.urihttp://hdl.handle.net/10451/55416
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/14714159pt_PT
dc.subjectA2A receptorpt_PT
dc.subjectAdenosinept_PT
dc.subjectCortico-striatal pathwaypt_PT
dc.subjectGlial cell line-derived neurotrophic factorpt_PT
dc.subjectGlutamatept_PT
dc.subjectRearranged during transfection/GDNF family receptor a1pt_PT
dc.titleGDNF control of the glutamatergic cortico-striatal pathway requires tonic activation of adenosine A2A receptorspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1219pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1208pt_PT
oaire.citation.titleJournal of Neurochemistrypt_PT
oaire.citation.volume108pt_PT
person.familyNameGomes
person.familyNameSebastião
person.familyNameCunha
person.familyNameRibeiro
person.givenNameCatarina
person.givenNameAna M
person.givenNameRodrigo
person.givenNameJoaquim
person.identifier29983
person.identifier.ciencia-idF112-55E8-E37E
person.identifier.ciencia-idCF1A-8BED-B840
person.identifier.ciencia-id081F-2518-907F
person.identifier.orcid0000-0001-9415-2109
person.identifier.orcid0000-0001-9030-6115
person.identifier.orcid0000-0003-2550-6422
person.identifier.orcid0000-0002-9330-3507
person.identifier.ridK-6218-2015
person.identifier.ridE-7475-2015
person.identifier.scopus-author-id7004409879
person.identifier.scopus-author-id7102879525
person.identifier.scopus-author-id35498669400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf881b87c-aea6-4506-af81-1f4a59de0dd8
relation.isAuthorOfPublication304abd7f-071b-4447-a8a3-4aa5f0547141
relation.isAuthorOfPublication14492f00-690a-4c58-8881-bac30a326f49
relation.isAuthorOfPublication86da944c-5e6a-4ec5-a56e-4ed82ece7a17
relation.isAuthorOfPublication.latestForDiscovery14492f00-690a-4c58-8881-bac30a326f49

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