A carregar...
Publicação
Choque séptico : patologia e terapêutica
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.18 MB | Adobe PDF |
Orientador(es)
Resumo(s)
A evolução das ciências médicas permitiu um significativo desenvolvimento de tratamentos e procedimentos que conduziram a um aumento da esperança média de vida da população mundial. Desta forma, patologias como a sépsis grave e o choque séptico tornaram-se das principais causas de morte no mundo, estimando-se o aparecimento anual de 1,5 milhões de novos casos na América do Norte e de 1,5 milhões na Europa. A sépsis e o choque séptico são caracterizados por uma resposta exacerbada do sistema imunitário, com libertação massiva de mediadores químicos que estão na origem da apoptose celular, lesão do endotélio e falha multiorgânica. Ainda não existe uma forma concisa de diagnóstico, pelo que continua a ser baseado na experiência dos profissionais de saúde e na avaliação dos sintomas apresentados, com a inclusão de factores clínicos, microbiológicos e biológicos. Para o tratamento, recomenda-se o uso de fluidos de reanimação e de fármacos vasopressores e inotrópicos, sempre que a primeira abordagem não seja suficiente para estabilizar a hipotensão induzida pelo estado séptico. Concluindo, futuramente novas abordagens serão necessárias de forma a colmatar os défices existentes a nível do diagnóstico e do tratamento, de forma a reduzir a mortalidade e morbilidade associada à sépsis e choque séptico.
The evolution of medical science has allowed a significant development of treatments and procedures that led to an increase in life expectancy of the world population. Thus, disorders such as severe sepsis and septic shock have become major causes of worldwide death, with an annual incidence of the 1.5 million new cases in North America and 1.5 million in Europe. Sepsis and septic shock are characterized by an extended response of the immune system with massive release of chemical mediators which cause cell apoptosis, endothelial injury and multiple organ failure. Although there is no concise diagnostic, this continues to be based on the experience of health professionals and the assessment of symptoms, with the inclusion of clinical, microbiological and biological factors. For treatment, it is recommended to use fluid resuscitation and vasopressors and inotropes when the first approach is not sufficient to stabilize the hypotension induced by sepsis. In conclusion, future new approaches will be needed in order to fill the existing gaps in terms of diagnosis and treatment to reduce mortality and morbidity associated with sepsis and septic shock.
The evolution of medical science has allowed a significant development of treatments and procedures that led to an increase in life expectancy of the world population. Thus, disorders such as severe sepsis and septic shock have become major causes of worldwide death, with an annual incidence of the 1.5 million new cases in North America and 1.5 million in Europe. Sepsis and septic shock are characterized by an extended response of the immune system with massive release of chemical mediators which cause cell apoptosis, endothelial injury and multiple organ failure. Although there is no concise diagnostic, this continues to be based on the experience of health professionals and the assessment of symptoms, with the inclusion of clinical, microbiological and biological factors. For treatment, it is recommended to use fluid resuscitation and vasopressors and inotropes when the first approach is not sufficient to stabilize the hypotension induced by sepsis. In conclusion, future new approaches will be needed in order to fill the existing gaps in terms of diagnosis and treatment to reduce mortality and morbidity associated with sepsis and septic shock.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014
Palavras-chave
Sépsis Choque séptico Citocinas Biomarcadores Fluidos de reanimação Vasopressores Mestrado Integrado - 2014