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Elimination of hepatic rodent plasmodium parasites by amino acid supplementation

2020Journal article Open access
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dc.contributor.authorMeireles, Patricia
dc.contributor.authorBrás, Daniela
dc.contributor.authorFontinha, Diana
dc.contributor.authorChora, Ângelo Ferreira
dc.contributor.authorSerre, Karine
dc.contributor.authorMendes, António M.
dc.contributor.authorPrudêncio, Miguel
dc.date.accessioned2021-04-07T12:31:35Z
dc.date.available2021-04-07T12:31:35Z
dc.date.issued2020
dc.description© 2020 The Authors.This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)pt_PT
dc.description.abstractPlasmodium parasites, causative agents of malaria, scavenge host nutrients to sustain their intracellular replication. Modulation of the host's nutritional status can potentially help control infection by limiting the parasite's access to nutrients, or by boosting the immune system. Here, we show that dietary supplementation of mice employing a combination of arginine (R) with two additional amino acids, lysine (K) and valine (V), termed RKV, significantly decreases Plasmodium liver infection. RKV supplementation results in the elimination of parasites at a late stage of their development in the liver. Our data employing genetic knockout mouse models and in vivo depletion of specific cell populations suggest that RKV supplementation boosts the host's overall innate immune response, and that parasite elimination is dependent on MyD88 signaling in immune cells. The immunostimulatory effect of RKV supplementation opens a potential role for dietary supplementation as an adjuvant for prophylaxis or immunization strategies against Plasmodium infection.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e a Tecnologia , Portugal, through Grant PTDC/SAU-INF/29550/2017 to MP.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationiScience. 2020 Nov 6;23(12):101781pt_PT
dc.identifier.doi10.1016/j.isci.2020.101781pt_PT
dc.identifier.eissn2589-0042
dc.identifier.urihttp://hdl.handle.net/10451/47274
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEnabling strategies for enhanced whole-sporozoite malaria vaccines
dc.relation.publisherversionhttps://www.cell.com/iscience/homept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDietpt_PT
dc.subjectParasitologypt_PT
dc.subjectPhysiologypt_PT
dc.titleElimination of hepatic rodent plasmodium parasites by amino acid supplementationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEnabling strategies for enhanced whole-sporozoite malaria vaccines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FSAU-INF%2F29550%2F2017/PT
oaire.citation.issue12pt_PT
oaire.citation.startPage101781pt_PT
oaire.citation.titleiSciencept_PT
oaire.citation.volume23pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameMeireles
person.familyNameBrás
person.familyNameFontinha
person.familyNameFerreira Chaves do Rosário Chora
person.familyNameSerre
person.familyNameM. Mendes
person.familyNamePrudêncio
person.givenNamePatricia
person.givenNameDaniela
person.givenNameDiana
person.givenNameÂngelo António
person.givenNameKarine
person.givenNameAntónio
person.givenNameMiguel
person.identifier120366
person.identifier361994
person.identifierhttps://scholar.google.pt/citations?user=zduN6wsAAAAJ&hl=pt-PT&oi=ao
person.identifier.ciencia-idF01B-91DA-7C52
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person.identifier.ciencia-id1E11-7283-DF35
person.identifier.ciencia-id4E15-FAB8-D7D1
person.identifier.ciencia-id5511-16ED-48E0
person.identifier.orcid0000-0002-9188-2808
person.identifier.orcid0000-0002-2667-3962
person.identifier.orcid0000-0002-0046-648X
person.identifier.orcid0000-0002-7941-7196
person.identifier.orcid0000-0001-9152-4739
person.identifier.orcid0000-0001-6562-5325
person.identifier.orcid0000-0003-1746-6029
person.identifier.scopus-author-id6602493849
person.identifier.scopus-author-id14028767900
person.identifier.scopus-author-id6603561872
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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