Logo do repositório
 
Publicação

Evolution of the variant surface glycoprotein family in African trypanosomes

2022Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorSilva Pereira, Sara
dc.contributor.authorJackson, Andrew P.
dc.contributor.authorFigueiredo, Luisa M.
dc.date.accessioned2022-01-04T14:07:54Z
dc.date.available2022-01-04T14:07:54Z
dc.date.issued2022
dc.description© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)pt_PT
dc.description.abstractAn intriguing and remarkable feature of African trypanosomes is their antigenic variation system, mediated by the variant surface glycoprotein (VSG) family and fundamental to both immune evasion and disease epidemiology within host populations. Recent studies have revealed that the VSG repertoire has a complex evolutionary history. Sequence diversity, genomic organization, and expression patterns are species-specific, which may explain other variations in parasite virulence and disease pathology. Evidence also shows that we may be underestimating the extent to what VSGs are repurposed beyond their roles as variant antigens, establishing a need to examine VSG functionality more deeply. Here, we review sequence variation within the VSG gene family, and highlight the many opportunities to explore their likely diverse contributions to parasite survival.pt_PT
dc.description.sponsorshipS.S.P. is funded by the European Union's Horizon 2020 research and innovation program through a Marie Skłodowska-Curie Individual Standard European Fellowship , under grant agreement no. 839960 . A.P.J. is funded by a Leverhulme Trust Research Fellowship ( RF-2020-413 ). L.M.F. is an Investigator CEEC of the Fundação para a Ciência e a Tecnologia ( CEECIND/03322/2018 ) and the laboratory is funded by the ERC (FatTryp, ref. 771714 ).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTrends Parasitol. 2022 Jan;38(1):23-36pt_PT
dc.identifier.doi10.1016/j.pt.2021.07.012pt_PT
dc.identifier.eissn1471-5007
dc.identifier.issn1471-4922
dc.identifier.urihttp://hdl.handle.net/10451/50689
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCEECIND/03322/2018pt_PT
dc.relationCharacterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins
dc.relation.publisherversionhttps://www.cell.com/trends/parasitology/homept_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAfrican trypanosomespt_PT
dc.subjectAfrican trypanosomiasispt_PT
dc.subjectAntigenic diversitypt_PT
dc.subjectAntigenic variationpt_PT
dc.subjectNaganapt_PT
dc.subjectVariant surface glycoproteinspt_PT
dc.titleEvolution of the variant surface glycoprotein family in African trypanosomespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCharacterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/839960/EU
oaire.citation.endPage36pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage23pt_PT
oaire.citation.titleTrends in Parasitologypt_PT
oaire.citation.volume38pt_PT
oaire.fundingStreamH2020
person.familyNameSilva Pereira
person.familyNameFigueiredo
person.givenNameSara
person.givenNameLuisa M
person.identifier.ciencia-id8B17-CF8D-E8CD
person.identifier.ciencia-id421C-420D-E7BD
person.identifier.orcid0000-0002-6590-6626
person.identifier.orcid0000-0002-5752-6586
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1aef6355-38a9-4ce5-9f2c-ac3beb8fee9e
relation.isAuthorOfPublication996632d8-b4b7-45ab-903f-aec092718a0d
relation.isAuthorOfPublication.latestForDiscovery996632d8-b4b7-45ab-903f-aec092718a0d
relation.isProjectOfPublication84f48bb7-1826-461d-a2e7-86af03859526
relation.isProjectOfPublication.latestForDiscovery84f48bb7-1826-461d-a2e7-86af03859526

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Evolution_variant.pdf
Tamanho:
2.28 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IMM - Artigos em Revistas Internacionais
FM - Artigos em Revistas Internacionais