Publication
Muscle is a stage, and cells and factors are merely players
| dc.contributor.author | Roman, William | |
| dc.contributor.author | Muñoz-Cánoves, Pura | |
| dc.date.accessioned | 2022-09-13T10:42:27Z | |
| dc.date.available | 2022-09-13T10:42:27Z | |
| dc.date.issued | 2022 | |
| dc.description | © 2022 Elsevier Ltd. All rights reserved. | pt_PT |
| dc.description.abstract | The incredible ability of satellite cells to regenerate muscle has captivated much of the research field's attention over the past decades. Versatile, enigmatic, vigorous, and skillful, the satellite cell is the optimal actor to cast in a regenerative epic, grabbing contracts and making headlines. However, the scenarios that play out during normal muscle usage, such as during exercise and aging, diverge from the experimental setup staged to spotlight satellite cells. Recent studies examining myofibers have highlighted novel attributes, including a capacity for self-repair. We discuss here the distinctions between myofiber self-repair and satellite-cell-dependent regeneration and how they may cooperate to repair damage after exercise, in myopathies, and in aging. | pt_PT |
| dc.description.sponsorship | Work in the authors’ laboratory has been supported by the following funding sources: Human Frontier Long-Term Fellowship (LT-LT000133/2018) W.R. MICINN [RTI2018-096068-B-I00, Maria de Maeztu Unit of Excellence award to UPF (MDM-2014-0370), Severo Ochoa Center of Excellence award to CNIC (SEV-2015-0505)], ERC-2016-AdG-741966, La Caixa-HEALTH-00040, MDA, LaMarato/TV3, UPGRADE-H2020-825825, MWRF, AFM, and DPPE to P.M.C. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Trends Cell Biol. 2022 Oct;32(10):835-840 | pt_PT |
| dc.identifier.doi | 10.1016/j.tcb.2022.03.001 | pt_PT |
| dc.identifier.eissn | 1879-3088 | |
| dc.identifier.issn | 0962-8924 | |
| dc.identifier.uri | http://hdl.handle.net/10451/54443 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation.publisherversion | https://www.sciencedirect.com/journal/trends-in-cell-biology | pt_PT |
| dc.subject | Aging | pt_PT |
| dc.subject | Exercise | pt_PT |
| dc.subject | Regeneration | pt_PT |
| dc.subject | Skeletal muscle | pt_PT |
| dc.subject | Stem cells | pt_PT |
| dc.title | Muscle is a stage, and cells and factors are merely players | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 840 | pt_PT |
| oaire.citation.issue | 10 | pt_PT |
| oaire.citation.startPage | 835 | pt_PT |
| oaire.citation.title | Trends in Cell Biology | pt_PT |
| oaire.citation.volume | 32 | pt_PT |
| person.familyName | Roman | |
| person.givenName | William | |
| person.identifier.ciencia-id | B018-06C2-085E | |
| person.identifier.orcid | 0000-0002-2210-0980 | |
| person.identifier.rid | I-4160-2017 | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 68fee748-a304-4464-a76a-8c2e5a1eb9dc | |
| relation.isAuthorOfPublication.latestForDiscovery | 68fee748-a304-4464-a76a-8c2e5a1eb9dc |