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Publicação
Genome Inspector: a web tool for exploring Bacterial genomes
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| 2.63 MB | Adobe PDF |
Orientador(es)
Resumo(s)
Genome Inspector (GIN) is a new interactive web-based application for exploring bacterial genomes designed to provide users with a wide choice of options to facilitate the process of designing DNA primers for isolating genes
from similar bacterial species and strains. GIN employs a project-based approach in which users can select any given set of available genomes and perform a comprehensive bioinformatics analysis. Currently, it encompasses the full set of annotated bacterial genomes available on GenBank, a total of 4300 files corresponding to over 740,000 annotated genes. GIN allows new data to be added directly from GenBank as it is being generated, as well as new genome uploading for personal analysis. The application interfaces were designed with potential users in mind to assist with their most common research goals. Users can visually explore full circular genomes, search for similar regions in other species and strains, and visualize amplified genomic regions for several strains simultaneously. This interactive tool allows for dynamic graphical exploration and refinement of search and exploration criteria. Furthermore, it includes a multiple alignment algorithm (MUSCLE) to help researchers in the process of designing primers. GIN is free and publicly available at http://gin.ul.pt/GIN2/index.php.
Descrição
Palavras-chave
Bioinformatics Web Application Genome Analysis Data Visualization Restriction endonucleases Campylobacter jejuni Helicobacter pylori
Contexto Educativo
Citação
Editora
Escola de Ciências e Tecnologia da Universidade de Évora