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Effects of the ketogenic diet in the treatment of gliomas: a systematic review

2022Journal article Open access
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dc.contributor.authorSargaço, Beatriz
dc.contributor.authorOliveira, Patrícia
dc.contributor.authorAntunes, Maria Luz
dc.contributor.authorMoreira, Ana Catarina
dc.date.accessioned2023-04-21T14:02:21Z
dc.date.available2023-04-21T14:02:21Z
dc.date.issued2022
dc.description© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThe ketogenic diet (KD) is a restrictive therapeutic diet, distinguished by being hyperlipidic, normoproteic, and hypoglucidic. This diet simulates biochemical changes related to fasting periods to achieve systemic ketosis. The metabolic particularities of glioma tumors motivated the rise in investigations and nutritional strategies, such as KD, to modulate the glycemic response as a treatment. This systematic review followed the PRISMA recommendations and was published in PROSPERO, with the identification CRD42021264173. The databases used were EMBASE, PubMed/Medline, Scopus, and Web of Science, and the studies were analyzed using the web-based application Rayyan. To analyze the risk of bias, Cochrane RevMan 5 software was used. For the analysis and treatment of statistical data, Microsoft® Excel® was used. A total of nine original articles were included. Data on survival, symptomology, and quality of life were collected. Mean overall survival was 15.9 months. Constipation and fatigue were the most reported symptoms. In 44.4% of the studies, an improvement in the quality of life was found. The KD is supported by most published studies as an effective therapy in the treatment of malignant gliomas due to its positive effects on patient survival. It was not possible to conclude the effectiveness of KD on quality of life.pt_PT
dc.description.sponsorshipThis study was part of the MSc thesis in clinical nutrition of one of the authors (B.S.), which was supervised by another author (supervisor A.C.M.) from the Faculty of Medicine of Lisbon and Lisbon School of Health Technology, Lisbon, Portugal. The H&TRC author gratefully acknowledges the FCT/MCTES national support through UIDB/05608/2020 and UIDP/05608/2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNutrients. 2022 Feb 27;14(5):1007pt_PT
dc.identifier.doi10.3390/nu14051007pt_PT
dc.identifier.eissn2072-6643
dc.identifier.urihttp://hdl.handle.net/10451/57227
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationHealth and Technology Research Center
dc.relationHealth and Technology Research Center
dc.relation.publisherversionhttps://www.mdpi.com/journal/nutrientspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGlioblastomapt_PT
dc.subjectGliomapt_PT
dc.subjectKetogenic dietpt_PT
dc.subjectSurvivalpt_PT
dc.titleEffects of the ketogenic diet in the treatment of gliomas: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth and Technology Research Center
oaire.awardTitleHealth and Technology Research Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05608%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F05608%2F2020/PT
oaire.citation.issue5pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSargaço
person.familyNameAlmeida Oliveira
person.familyNameMoreira
person.givenNameBeatriz
person.givenNamePatrícia
person.givenNameAna Catarina
person.identifier.ciencia-id421B-C686-77E0
person.identifier.ciencia-idC81E-CC41-DFB0
person.identifier.orcid0000-0003-1551-9529
person.identifier.orcid0000-0003-2844-8934
person.identifier.orcid0000-0001-7031-6738
person.identifier.scopus-author-id16234261500
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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