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The Mediterranean diet, and not dietary inflammatory index, is associated with rheumatoid arthritis disease activity, the impact of disease and functional disability

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dc.contributor.authorCharneca, Sofia
dc.contributor.authorFerro, Margarida
dc.contributor.authorVasques, João
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorMartins-Martinho, Joana
dc.contributor.authorDuarte-Monteiro, Ana Margarida
dc.contributor.authorDourado, Eduardo
dc.contributor.authorFonseca, João Eurico
dc.contributor.authorGuerreiro, Catarina Sousa
dc.date.accessioned2023-07-18T11:08:50Z
dc.date.available2023-07-18T11:08:50Z
dc.date.issued2023
dc.description© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2023.pt_PT
dc.description.abstractPurpose: To assess the relationship between adherence to the Mediterranean Diet (MD) /individual Dietary Inflammatory Index (DII) and disease activity, disease impact, and functional status in Rheumatoid Arthritis (RA) patients. Methods: RA patients followed at a hospital in Lisbon, Portugal, were recruited. DII was calculated using dietary intake data collected with a food frequency questionnaire (FFQ). Adherence to the MD was obtained using the 14-item Mediterranean Diet assessment tool. Disease Activity Score of 28 Joints (DAS28) and the DAS28 calculated with C-Reactive Protein (DAS28-CRP) were used to assess disease activity. Impact of disease and functional status were evaluated using the Rheumatoid Arthritis Impact of Disease (RAID) questionnaire and the Health Assessment Questionnaire (HAQ), respectively. Results: 120 patients (73.3% female, 61.8 ± 10.1 years of age) were included. Patients with higher adherence to the MD had significantly lower DAS28-CRP (median 3.27(2.37) vs 2.77(1.49), p = 0.030), RAID (median 5.65(2.38) vs 3.51(4.51), p = 0.032) and HAQ (median 1.00(0.56) vs 0.56(1.03), p = 0.013) scores. Higher adherence to the MD reduced the odds of having a higher DAS28 by 70% (OR = 0.303, 95%CI = (0.261, 0.347), p = 0.003). Lower adherence to MD was associated with higher DAS28-CRP (β = - 0.164, p = 0.001), higher RAID (β = - 0.311, p < 0.0001), and higher HAQ scores (β = - 0.089, p = 0.001), irrespective of age, gender, BMI and pharmacological therapy. Mean DII of our cohort was not significantly different from the Portuguese population (0.00 ± 0.17 vs - 0.10 ± 1.46, p = 0.578). No associations between macronutrient intake or DII and RA outcomes were found. Conclusions: Higher adherence to the MD was associated with lower disease activity, lower impact of disease, and lower functional disability in RA patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Nutr. 2023 Jun 24pt_PT
dc.identifier.doi10.1007/s00394-023-03196-8pt_PT
dc.identifier.eissn1436-6215
dc.identifier.issn1436-6207
dc.identifier.urihttp://hdl.handle.net/10451/58648
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/394pt_PT
dc.subjectDisease activitypt_PT
dc.subjectDisease impactpt_PT
dc.subjectFunctional disabilitypt_PT
dc.subjectMediterranean dietpt_PT
dc.subjectRheumatoid arthritispt_PT
dc.titleThe Mediterranean diet, and not dietary inflammatory index, is associated with rheumatoid arthritis disease activity, the impact of disease and functional disabilitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEuropean Journal of Nutritionpt_PT
person.familyNameChinita Charneca
person.familyNameFerro
person.familyNameVasques
person.familyNameCarolino
person.familyNameDOURADO DOMINGUES
person.familyNameFonseca
person.familyNamesousa guerreiro
person.givenNameSofia Margarida
person.givenNameMargarida
person.givenNameJoão
person.givenNameElisabete
person.givenNameEDUARDO JORGE
person.givenNameJoão
person.givenNamecatarina
person.identifier2684661
person.identifier.ciencia-idFC12-D310-411E
person.identifier.ciencia-idB111-4ED5-F8E6
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.ciencia-id531B-BA03-FCA0
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.ciencia-id311F-89E5-532C
person.identifier.orcid0000-0002-0426-0462
person.identifier.orcid0000-0002-7549-2391
person.identifier.orcid0000-0001-9928-9331
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0003-2186-2833
person.identifier.orcid0000-0003-1432-3671
person.identifier.orcid0000-0002-8730-6517
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id7101983519
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication56b53cfb-9ad2-48c1-a625-15cf813a4045
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relation.isAuthorOfPublication.latestForDiscovery1772dc12-7c55-4c76-ae2d-c23270172480

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