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The influence of the preparation methods on the inclusion of model drugs in a beta-cyclodextrin cavity

2009Artigo científico Apenas metadados
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dc.contributor.authorSalustio, P. J.
dc.contributor.authorFeio, G.
dc.contributor.authorFigueirinhas, J. L.
dc.contributor.authorPinto, J. F.
dc.contributor.authorMarques, Helena
dc.date.accessioned2015-12-30T10:16:58Z
dc.date.available2015-12-30T10:16:58Z
dc.date.issued2009
dc.description.abstractThe work aims to prove the complexation of two model drugs (ibuprofen, IB and indomethacin, IN) by beta-cyclodextrin (beta CD), and the effect of water in such a process, and makes a comparison of their complexation yields. Two methods were considered: kneading of a binary mixture of the drug, beta CD, and inclusion of either IB or IN in aqueous solutions of beta CD. In the latter method water was removed by air stream, spray-drying and freeze-drying. To prove the formation of complexes in final products, optical microscopy, UV spectroscopy, IR spectroscopy, DSC, X-ray and NMR were considered. Each powder was added to an acidic solution (pH = 2) to quantify the concentration of the drug inside beta CD cavity. Other media (pH = 5 anti 7) were used to prove the existence of drug not complexed in each powder, as the drugs Solubility increases with the pH. It was observed that complexation occurred in all powders, and that the fraction of drug inside the beta CD did not depend neither oil the method of complexation nor on the processes of drying considered. (C) 2008 Elsevier B.V. All rights reserved.
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dc.identifier.citationEUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. - Vol. 71, n. 2 (FEB 2009), p. 377-386
dc.identifier.doihttp://dx.doi.org/10.1016/j.ejpb.2008.09.027
dc.identifier.issn0939-6411
dc.identifier.urihttp://hdl.handle.net/10451/20880
dc.language.isoeng
dc.publisherELSEVIER SCIENCE BV
dc.subjectPharmacology & Pharmacy
dc.titleThe influence of the preparation methods on the inclusion of model drugs in a beta-cyclodextrin cavity
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage386por
oaire.citation.startPage377por
oaire.citation.titleEUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICSpor
oaire.citation.volumeVol. 71por
person.familyNameMarques
person.givenNameHelena
person.identifier.ciencia-idDB1F-B511-D3F2
person.identifier.orcid0000-0002-9255-4697
person.identifier.ridA-9739-2014
person.identifier.scopus-author-id6603071227
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicationb30c4f1a-38da-49ed-bfa7-24e6eb08f072
relation.isAuthorOfPublication.latestForDiscoveryb30c4f1a-38da-49ed-bfa7-24e6eb08f072

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