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Pubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversing activity on mouse lymphoma cells

2004Journal article Metadata only
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dc.contributor.authorValente, C
dc.contributor.authorFerreira, MJU
dc.contributor.authorAbreu, PM
dc.contributor.authorGyemant, N
dc.contributor.authorUgocsai, K
dc.contributor.authorHohmann, J
dc.contributor.authorMolnar, J
dc.date.accessioned2015-12-30T10:18:08Z
dc.date.available2015-12-30T10:18:08Z
dc.date.issued2004
dc.description.abstractThe macrocyclic jatrophane diterpene polyesters, pubescenes A-D (1-4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D (4) is a new compound, whose structure was established as 3beta9alpha,-diacetoxy-7beta-benzoyloxy-15beta-hydroxy-14-oxo-2betaH-jatropha-5E,12E-diene by spectroscopic methods, including H-1-H-1 COSY, HMQC, HMBC and NOESY.
dc.formatapplication/pdf
dc.identifier.citationPLANTA MEDICA. - Vol. 70, n. 1 (JAN 2004), p. 81-84
dc.identifier.doihttp://dx.doi.org/10.1055/s-2004-815464
dc.identifier.issn0032-0943
dc.identifier.urihttp://hdl.handle.net/10451/21429
dc.language.isoeng
dc.publisherGEORG THIEME VERLAG KG
dc.subjectPlant Sciences
dc.subjectChemistry, Medicinal
dc.subjectPharmacology & Pharmacy
dc.titlePubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversing activity on mouse lymphoma cells
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage84por
oaire.citation.startPage81por
oaire.citation.titlePLANTA MEDICApor
oaire.citation.volumeVol. 70por
rcaap.rightsrestrictedAccess
rcaap.typearticle

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