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Intestinal barrier interactions with specialized CD8 T Cells

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dc.contributor.authorKonjar, Spela
dc.contributor.authorFerreira, Cristina
dc.contributor.authorBlankenhaus, Birte
dc.contributor.authorVeldhoen, Marc
dc.date.accessioned2021-09-22T16:50:01Z
dc.date.available2021-09-22T16:50:01Z
dc.date.issued2017
dc.descriptionCopyright: © 2017 Konjar, Ferreira, Blankenhaus and Veldhoen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractThe trillions of microorganisms that reside in the gastrointestinal tract, essential for nutrient absorption, are kept under control by a single cell barrier and large amounts of immune cells. Intestinal epithelial cells (IECs) are critical in establishing an environment supporting microbial colonization and immunological tolerance. A large population of CD8+ T cells is in direct and constant contact with the IECs and the intraepithelial lymphocytes (IELs). Due to their location, at the interphase of the intestinal lumen and external environment and the host tissues, they seem ideally positioned to balance immune tolerance and protection to preserve the fragile intestinal barrier from invasion as well as immunopathology. IELs are a heterogeneous population, with a large innate-like contribution of unknown specificity, intercalated with antigen-specific tissue-resident memory T cells. In this review, we provide a comprehensive overview of IEL physiology and how they interact with the IECs and contribute to immune surveillance to preserve intestinal homeostasis and host-microbial relationships.pt_PT
dc.description.sponsorshipMembers of the Veldhoen laboratory are supported by European Union H2020 ERA project (N°667824—EXCELLtoINNOV), publication costs were provided by LISBOA-01-0145-FEDER-007391, projeto cofinanciado pelo FEDER através POR Lisboa 2020—Programa Operacional Regional de Lisboa, do PORTUGAL 2020, e pela Fundação para a Ciência e a Tecnologia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Immunol. 2017 Oct 11;8:1281pt_PT
dc.identifier.doi10.3389/fimmu.2017.01281pt_PT
dc.identifier.eissn1664-3224
dc.identifier.urihttp://hdl.handle.net/10451/49575
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationLISBOA-01-0145-FEDER-007391pt_PT
dc.relationLeverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.
dc.relation.publisherversionhttps://www.frontiersin.org/journals/immunologypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCD8+ T-lymphocytespt_PT
dc.subjectEpithelial cellspt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.subjectIntraepithelial lymphocytespt_PT
dc.subjectMucosal immunologypt_PT
dc.titleIntestinal barrier interactions with specialized CD8 T Cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLeverage research EXCELLence and INNOVation potential of Instituto de Medicina Molecular (IMM) through translational biomedical research in immunity and infection.
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/667824/EU
oaire.citation.titleFrontiers in Immunologypt_PT
oaire.citation.volume8pt_PT
oaire.fundingStreamH2020
person.familyNameKonjar
person.familyNameFerreira
person.familyNameBlankenhaus
person.familyNameVeldhoen
person.givenNameSpela
person.givenNameCristina
person.givenNameBirte
person.givenNameMarc
person.identifierhttps://scholar.google.pt/citations?hl=en&user=7vG1jLIAAAAJ
person.identifier.ciencia-idFD19-D7A4-E29D
person.identifier.ciencia-id6413-A3A0-C7AD
person.identifier.orcid0000-0002-8969-0233
person.identifier.orcid0000-0001-6746-932X
person.identifier.orcid0000-0003-0987-5228
person.identifier.orcid0000-0002-1478-9562
person.identifier.scopus-author-id8323789000
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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