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Circulating tumor cell detection methods in renal cell carcinoma : a systematic review

2021-04-20Journal article Restricted access
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dc.contributor.authorPalmela Leitão, Tito
dc.contributor.authorMiranda, Miguel
dc.contributor.authorPolido, Joana
dc.contributor.authorMorais, João
dc.contributor.authorCorredeira, Patrícia
dc.contributor.authorAlves, Patrícia
dc.contributor.authorRibeiro-de-Oliveira, Tiago
dc.contributor.authorPereira E Silva, Ricardo
dc.contributor.authorFernandes, Ricardo M.
dc.contributor.authorFerreira, João
dc.contributor.authorReis, José Palma
dc.contributor.authorLopes, Tomé
dc.contributor.authorCosta, Luis
dc.date.accessioned2021-04-30T13:43:41Z
dc.date.available2021-04-30T13:43:41Z
dc.date.issued2021-04-20
dc.description© 2021 Elsevier B.V. All rights reserved.pt_PT
dc.description.abstractCirculating tumor cells (CTCs) have a potential role as the missing renal cell carcinoma (RCC) biomarker. However, the available evidence is limited, and detection methods lack standardization, hindering clinical use. We performed a systematic review on CTC enrichment and detection methods, and its role as a biomarker in RCC. Full-text screening identified 54 studies. Reviewed studies showed wide heterogeneity, low evidence level, and high risk of bias. Various CTC detection platforms and molecular markers have been used, but none has proven to be superior. CTC detection and CTC count seem to correlate with staging and survival outcomes, although evidence is inconsistent. CTC research is still in an exploratory phase, particularly in RCC. Further studies are still necessary to achieve a standardization of techniques, molecular markers, CTC definitions, and terminology. This is essential to ascertain the role of CTCs as a biomarker and guide future liquid biopsy research in RCC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCrit Rev Oncol Hematol. 2021 Apr 20;161:103331pt_PT
dc.identifier.doi10.1016/j.critrevonc.2021.103331pt_PT
dc.identifier.eissn1879-0461
dc.identifier.issn1040-8428
dc.identifier.urihttp://hdl.handle.net/10451/47621
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/critical-reviews-in-oncology-hematologypt_PT
dc.subjectBiomarkerpt_PT
dc.subjectCirculating tumor cellspt_PT
dc.subjectLiquid biopsypt_PT
dc.subjectMetastasespt_PT
dc.subjectRenal cell carcinomapt_PT
dc.titleCirculating tumor cell detection methods in renal cell carcinoma : a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleCritical Reviews in Oncology/Hematologypt_PT
oaire.citation.volume161pt_PT
person.familyNamePalmela Leitão
person.familyNamePolido
person.familyNameMartins Corredeira
person.familyNameAlves
person.familyNameRibeiro-de-Oliveira
person.familyNamePereira e Silva
person.familyNameFernandes
person.familyNameCosta
person.givenNameTito
person.givenNameJoana
person.givenNamePatrícia Isabel
person.givenNamePatrícia
person.givenNameTiago
person.givenNameRicardo
person.givenNameRicardo
person.givenNameLuis
person.identifier309018
person.identifier.ciencia-id4215-C7AD-F361
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person.identifier.ciencia-id041E-4ADE-FB64
person.identifier.orcid0000-0002-0075-6196
person.identifier.orcid0000-0002-8853-9486
person.identifier.orcid0000-0001-7075-3516
person.identifier.orcid0000-0001-9859-8618
person.identifier.orcid0000-0003-3196-1886
person.identifier.orcid0000-0002-4396-4921
person.identifier.orcid0000-0002-7253-6475
person.identifier.orcid0000-0002-4782-7318
person.identifier.ridW-1038-2018
person.identifier.ridH-3802-2014
person.identifier.ridC-7501-2015
person.identifier.scopus-author-id55491087200
person.identifier.scopus-author-id24436565500
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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