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Detection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomes

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dc.contributor.authorQuerido, Sara
dc.contributor.authorWeigert, Andre
dc.contributor.authorPinto, Iola
dc.contributor.authorPapoila, Ana Luísa
dc.contributor.authorPessanha, Maria Ana
dc.contributor.authorGomes, Perpétua
dc.contributor.authorAdragão, Teresa
dc.contributor.authorPaixão, Paulo
dc.date.accessioned2023-05-31T14:10:44Z
dc.date.available2023-05-31T14:10:44Z
dc.date.issued2023
dc.description© 2023 Wiley Periodicals LLC.pt_PT
dc.description.abstractStudies analyzing the relationship between BK polyomavirus (BKV) or JC polyomavirus (JCV) infection and kidney transplant (KT) long term clinical outcomes are scarce. Therefore, we evaluated this relationship in a single-center retrospective cohort of 288 KT patients followed for 45.4(27.5; 62.5) months. Detection of BKV viremia in two consecutive analyses led to discontinuation of antimetabolite and initiation of mammalian target of rapamycin inhibitor. Outcome data included de novo BKV and/or JCV viremia and/or viruria after KT, death-censored graft survival and patient survival. BKV viruria and viremia were detected in 42.4% and 22.2% of KT recipients, respectively. BKV viremic patients had higher urinary BKV viral loads at the onset of viruria, when compared to nonviremic patients (7 log10 vs. 4.9 log10 cp/mL, p < 0.001). JCV viruria was identified in 38.5% of KT patients; the 5.9% of KT recipients who developed JCV viremia had higher JCV urinary viral loads at the onset of viruria, when compared to non-viremic patients (5.3 vs. 3.7 log10 cp/mL, p = 0.034). No differences were found in estimated glomerular filtration rate at the end of follow up, when comparing BKV or JCV viruric or viremic patients with nonviremic patients. No association was found between JCV or BKV viruria or viremia and death/graft failure. Therefore, higher BKV urinary viral loads at the onset could serve as an early maker of over immunosuppression. JCV and BKV replication was not associated with inferior clinical outcomes in KT patients with the above-mentioned immunosuppression strategy.pt_PT
dc.description.sponsorshipAna Luisa Papoila work is partially financed by national funds through FCT—Fundação para a Ciência e a Tecnologia under the project UIDB/00006/2020. Iola Pinto work is funded by national funds through the FCT—Fundação para a Ciência e a Tecnologia, I.P., under the scope of the projects UIDB/00297/2020 and UIDP/00297/2020 (Center for Mathematics and Applications).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Med Virol. 2023 May;95(5):e28800pt_PT
dc.identifier.doi10.1002/jmv.28800pt_PT
dc.identifier.eissn1096-9071
dc.identifier.issn0146-6615
dc.identifier.urihttp://hdl.handle.net/10451/57726
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationCentre of Statistics and its Applications
dc.relationCenter for Mathematics and Applications
dc.relationCenter for Mathematics and Applications
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/10969071pt_PT
dc.subjectBK viruspt_PT
dc.subjectJC viruspt_PT
dc.subjectKidney transplantationpt_PT
dc.titleDetection of JCV or BKV viruria and viremia after kidney transplantation is not associated with unfavorable outcomespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/00006/2020
oaire.awardNumberUIDB/00297/2020
oaire.awardNumberUIDP/00297/2020
oaire.awardTitleCentre of Statistics and its Applications
oaire.awardTitleCenter for Mathematics and Applications
oaire.awardTitleCenter for Mathematics and Applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00297%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00297%2F2020/PT
oaire.citation.issue5pt_PT
oaire.citation.titleJournal of Medical Virologypt_PT
oaire.citation.volume95pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameWeigert
person.givenNameAndre
person.identifier.orcid0000-0001-9674-8862
person.identifier.scopus-author-id6701773162
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3dce3d11-aef1-4833-892e-489cecb20544
relation.isAuthorOfPublication.latestForDiscovery3dce3d11-aef1-4833-892e-489cecb20544
relation.isProjectOfPublicationca107901-755e-4fbf-9325-2bfcd9106576
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