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Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases

2019-02-06Journal article Open access
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dc.contributor.authorMansinho, André
dc.contributor.authorFerreira, Arlindo
dc.contributor.authorCasimiro, Sandra
dc.contributor.authorAlho, Irina
dc.contributor.authorVendrell, Ines
dc.contributor.authorCosta, Ana Lúcia
dc.contributor.authorSousa, Rita
dc.contributor.authorMarques, Catarina
dc.contributor.authorPulido, Catarina
dc.contributor.authorMacedo, Daniela
dc.contributor.authorPacheco, Teresa
dc.contributor.authorCorreia, Lurdes
dc.contributor.authorCosta, Luis
dc.date.accessioned2021-07-29T13:36:02Z
dc.date.available2021-07-29T13:36:02Z
dc.date.issued2019-02-06
dc.description© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThe fibroblast growth factor (FGF) signaling pathway plays a key role in tumorigenesis and is recognized as a potential therapeutic target. In this study, the authors aimed to assess the impact of serum FGF23 levels in the prognosis of patients with cancer and bone metastases from solid tumors. A cohort of 112 patients with cancer and metastatic bone disease were treated with bone-targeted agents (BTA). Serum baseline FGF23 was quantified by ELISA and dichotomized in FGF23high and FGF23low groups. Additionally, the association between FGF23 and overall survival (OS) and time to skeletal-related events (TTSRE) was investigated. Baseline characteristics were balanced between groups, except for the median urinary N-terminal telopeptide (uNTX) level. After a median follow-up of 26.0 months, a median OS of 34.4 and 12.2 months was found in the FGF23low and FGF23high groups, respectively (multivariate HR 0.18, 95% CI 0.07⁻0.44, p = 0.001; univariate HR 0.27, p = 0.001). Additionally, TTSRE was significantly longer for patients with FGF23low (13.0 vs 2.0 months, p = 0.04). Overall, this study found that patients with FGF23low at baseline had longer OS and TTSRE. Further studies are warranted to define its role as a prognostic biomarker and in the use of drugs targeting the FGF axis.pt_PT
dc.description.sponsorshipThis research received funding from an anonymous non-pharma related individual in the form of donation. This study was supported by project UID/BIM/50005/2019 of Fundação para a Ciência e a Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through State Budget funding.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMansinho A, Ferreira AR, Casimiro S, Alho I, Vendrell I, Costa AL, Sousa R, Abreu C, Pulido C, Macedo D, Pacheco TR, Correia L, Costa L. Levels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastases. Int J Mol Sci. 2019 Feb 6;20(3):695pt_PT
dc.identifier.doi10.3390/ijms20030695pt_PT
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10451/49209
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationInstituto de Medicina Molecular
dc.relation.publisherversionhttps://www.mdpi.com/journal/ijmspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFGF23pt_PT
dc.subjectBone metastasespt_PT
dc.subjectCancerpt_PT
dc.subjectPrognosispt_PT
dc.titleLevels of circulating Fibroblast Growth Factor 23 (FGF23) and prognosis in cancer patients with bone metastasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInstituto de Medicina Molecular
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIM%2F50005%2F2019/PT
oaire.citation.issue3pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume20pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMansinho
person.familyNameFerreira
person.familyNameCara de Anjo Casimiro
person.familyNameDuarte
person.familyNameVendrell
person.familyNameSousa
person.familyNameMarques
person.familyNameMacedo
person.familyNamePacheco
person.familyNameCosta
person.givenNameAndré
person.givenNameArlindo
person.givenNameSandra Cristina
person.givenNameIrina
person.givenNameInes
person.givenNameRita
person.givenNameCatarina
person.givenNameDaniela
person.givenNameTeresa
person.givenNameLuis
person.identifier.ciencia-id7614-C999-F6C7
person.identifier.ciencia-idF112-254C-6DC4
person.identifier.ciencia-id0F12-5181-0B22
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person.identifier.ciencia-idB311-6AE6-9A83
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person.identifier.orcid0000-0002-5506-0233
person.identifier.orcid0000-0002-4782-7318
person.identifier.scopus-author-id56707990400
person.identifier.scopus-author-id14043403400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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