Publication
Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices
| dc.contributor.author | Sa de Almeida, Joana | |
| dc.contributor.author | Vargas, Mariana | |
| dc.contributor.author | Fonseca-Gomes, João | |
| dc.contributor.author | Tanqueiro, Sara | |
| dc.contributor.author | Belo, Rita F. | |
| dc.contributor.author | Miranda-Lourenço, Catarina | |
| dc.contributor.author | Sebastião, Ana M | |
| dc.contributor.author | Diógenes, Maria José | |
| dc.contributor.author | Pais, Teresa F. | |
| dc.date.accessioned | 2022-12-06T12:21:18Z | |
| dc.date.available | 2022-12-06T12:21:18Z | |
| dc.date.issued | 2020 | |
| dc.description | Copyright © 2020 Sa de Almeida, Vargas, Fonseca-Gomes, Tanqueiro, Belo, Miranda-Lourenço, Sebastião, Diógenes and Pais. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | pt_PT |
| dc.description.abstract | Microglial cells have emerged as crucial players in synaptic plasticity during development and adulthood, and also in neurodegenerative and neuroinflammatory conditions. Here we found that decreased levels of Sirtuin 2 (Sirt2) deacetylase in microglia affects hippocampal synaptic plasticity under inflammatory conditions. The results show that long-term potentiation (LTP) magnitude recorded from hippocampal slices of wild type mice does not differ between those exposed to lipopolysaccharide (LPS), a pro-inflammatory stimulus, or BSA. However, LTP recorded from hippocampal slices of microglial-specific Sirt2 deficient (Sirt2-) mice was significantly impaired by LPS. Importantly, LTP values were restored by memantine, an antagonist of N-methyl-D-aspartate (NMDA) receptors. These results indicate that microglial Sirt2 prevents NMDA-mediated excitotoxicity in hippocampal slices in response to an inflammatory signal such as LPS. Overall, our data suggest a key-protective role for microglial Sirt2 in mnesic deficits associated with neuroinflammation. | pt_PT |
| dc.description.sponsorship | This study was supported by Santa Casa da Misericórdia de Lisboa (MB37-2017), GAPIC Research Program of the University of Lisbon Medical School (n° 2014002 and n° 2015028) and the following doctoral grants: PD/BD/128091/2016, SFRH/BD/118238/2016, PD/BD/114337/2016, and PD/BD/1144- 41/2016. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Front Neurosci. 2020 Jun 18;14:614 | pt_PT |
| dc.identifier.doi | 10.3389/fnins.2020.00614 | pt_PT |
| dc.identifier.eissn | 1662-453X | |
| dc.identifier.issn | 1662-4548 | |
| dc.identifier.uri | http://hdl.handle.net/10451/55347 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Frontiers | pt_PT |
| dc.relation | Modulation of BDNF effects by adenosine: a new strategy for schizophrenia treatment - Adenosinergic signaling as a new pharmacological target for schizophrenia treatment | |
| dc.relation | Regulation of adenosine levels as a new therapeutic strategy for Rett Syndrome | |
| dc.relation | Kyotorphin as new pharmacological therapeutic strategy for Alzheimers Disease | |
| dc.relation | BDNF receptor cleavage:relevance for Alzheimer´s Disease pathophysiology | |
| dc.relation.publisherversion | https://www.frontiersin.org/journals/neuroscience | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Long-term potentiation | pt_PT |
| dc.subject | Memantine | pt_PT |
| dc.subject | Microglia | pt_PT |
| dc.subject | Neuroinfalmmation | pt_PT |
| dc.subject | Sirtuin 2 | pt_PT |
| dc.title | Microglial Sirtuin 2 shapes long-term potentiation in hippocampal slices | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Modulation of BDNF effects by adenosine: a new strategy for schizophrenia treatment - Adenosinergic signaling as a new pharmacological target for schizophrenia treatment | |
| oaire.awardTitle | Regulation of adenosine levels as a new therapeutic strategy for Rett Syndrome | |
| oaire.awardTitle | Kyotorphin as new pharmacological therapeutic strategy for Alzheimers Disease | |
| oaire.awardTitle | BDNF receptor cleavage:relevance for Alzheimer´s Disease pathophysiology | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//PD%2FBD%2F128091%2F2016/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F118238%2F2016/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//PD%2FBD%2F114337%2F2016/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT//PD%2FBD%2F114441%2F2016/PT | |
| oaire.citation.title | Frontiers in Neuroscience | pt_PT |
| oaire.citation.volume | 14 | pt_PT |
| person.familyName | Fonseca-Gomes | |
| person.familyName | Tanqueiro | |
| person.familyName | Belo | |
| person.familyName | Miranda Lourenço | |
| person.familyName | Sebastião | |
| person.familyName | de Oliveira Diógenes Nogueira | |
| person.givenName | João | |
| person.givenName | Sara | |
| person.givenName | Rita | |
| person.givenName | Catarina | |
| person.givenName | Ana M | |
| person.givenName | Maria José | |
| person.identifier | 697312 | |
| person.identifier.ciencia-id | A217-D5D0-E9BF | |
| person.identifier.ciencia-id | 6818-4322-9ED9 | |
| person.identifier.ciencia-id | FD1C-081D-1670 | |
| person.identifier.ciencia-id | A815-F59B-47E2 | |
| person.identifier.ciencia-id | F112-55E8-E37E | |
| person.identifier.ciencia-id | 4B10-886B-DAFC | |
| person.identifier.orcid | 0000-0001-7915-3517 | |
| person.identifier.orcid | 0000-0002-9151-7149 | |
| person.identifier.orcid | 0000-0002-4553-3455 | |
| person.identifier.orcid | 0000-0002-9633-7999 | |
| person.identifier.orcid | 0000-0001-9030-6115 | |
| person.identifier.orcid | 0000-0001-5486-6246 | |
| person.identifier.scopus-author-id | 7004409879 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 27eb0467-74b8-4947-9aaa-c6dd2c3e414c | |
| relation.isAuthorOfPublication | 4eba7e76-6608-4939-8206-d4c713d9f109 | |
| relation.isAuthorOfPublication | fd23da02-b7f8-4f3a-b797-5ea5cbe4a89a | |
| relation.isAuthorOfPublication | ac84bb9d-5767-4c17-bfe7-7b508cd0b804 | |
| relation.isAuthorOfPublication | 304abd7f-071b-4447-a8a3-4aa5f0547141 | |
| relation.isAuthorOfPublication | 15580af4-c3d5-491e-8ab5-bdc7d3c587a3 | |
| relation.isAuthorOfPublication.latestForDiscovery | 27eb0467-74b8-4947-9aaa-c6dd2c3e414c | |
| relation.isProjectOfPublication | b0d32d85-a98a-42a1-be51-7ceca8459454 | |
| relation.isProjectOfPublication | 5c0850e9-a502-4fc2-b0f5-f2e89fcefec3 | |
| relation.isProjectOfPublication | 71316492-61e5-47df-9e85-b7350a218b63 | |
| relation.isProjectOfPublication | 9e52a2c0-3c41-434b-8416-856951deba40 | |
| relation.isProjectOfPublication.latestForDiscovery | 9e52a2c0-3c41-434b-8416-856951deba40 |