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Chitosan/PVA Based Membranes Processed by Gamma Radiation as Scaffolding Materials for Skin Regeneration

2021-07Artigo científico Acesso aberto
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dc.contributor.authorCasimiro, Maria Helena
dc.contributor.authorPereira, Andreia
dc.contributor.authorLeal, João P.
dc.contributor.authorRodrigues, Gabriela
dc.contributor.authorFerreira, Luís M.
dc.date.accessioned2022-02-15T11:42:58Z
dc.date.available2022-02-15T11:42:58Z
dc.date.issued2021-07
dc.description.abstractSome of the current strategies for the development of scaffolding materials capable of inducing tissue regeneration have been based on the use of polymeric biomaterials. Chitosan, in particular, due to its recognized biological activity has been used in a number of biomedical applications. Aiming the development of chitosan-based membranes with improved cell adhesion and growth properties to be used as skin scaffolds allowing functional tissue replacement, different formulations with chitosan of different molecular weight, poly (vinyl alcohol) and gelatin, were evaluated. To meet the goal of getting ready-to-use scaffolds assuring membranes’ required properties and sterilization, preparation methodology included a lyophilization procedure followed by a final gamma irradiation step. Two radiation dose values were tested. Samples were characterized by TGA, FTIR, and SEM techniques. Their hydrophilic properties, in vitro stability, and biocompatibility were also evaluated. Results show that all membranes present a sponge-type inner structure. Chitosan of low molecular weight and the introduction of gelatin are more favorable to cellular growth leading to an improvement on cells’ morphology and cytoskeletal organization, giving a good perspective to the use of these membranes as potential skin scaffolds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCasimiro, M.H.; Pereira, A.; Leal, J.P.; Rodrigues, G.; Ferreira, L.M. Chitosan/PVA Based Membranes Processed by Gamma Radiation as Scaffolding Materials for Skin Regeneration. Membranes 2021, 11, 561. https://doi.org/10.3390/ membranes11080561pt_PT
dc.identifier.doi10.3390/membranes11080561pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/51306
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationInternational Atomic Energy Agency under Research Contract No. 18202 (CRP F23030)pt_PT
dc.relationFCT UID/Multi/04349/2019,pt_PT
dc.relationFCT UIDB/00100/2020pt_PT
dc.relationFCT UID/BIA/00329/2019pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleChitosan/PVA Based Membranes Processed by Gamma Radiation as Scaffolding Materials for Skin Regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.startPage561pt_PT
oaire.citation.titleMembranespt_PT
oaire.citation.volume11pt_PT
person.familyNameGomes de Figueiredo Rodrigues
person.givenNameMaria Gabriela
person.identifierA-1909-2013
person.identifier.ciencia-idF818-6DBC-0176
person.identifier.orcid0000-0002-0598-4040
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa1781bc5-e40b-4139-bd72-9a80d712fca1
relation.isAuthorOfPublication.latestForDiscoverya1781bc5-e40b-4139-bd72-9a80d712fca1

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