Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta 1-induced apoptosis of rat hepatocytes

Sola, S; Ma, XM; Castro, RE; Kren, BT; Steer, CJ; Rodrigues, CMP

http://hdl.handle.net/10451/21065

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Transforming growth factor beta1 (TGF-beta1)-induced hepatocyte apoptosis is associated with activation of E2F transcription factors and p53 stabilization through Mdm-2, thus potentially modulating a number of target genes. In previous studies, we have sh

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Biochemistry & Molecular Biology

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http://hdl.handle.net/10451/21065

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JOURNAL OF BIOLOGICAL CHEMISTRY. - Vol. 278, n. 49 (DEC 5 2003), p. 48831-48838

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AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

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http://dx.doi.org/10.1074/jbc.M300468200

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FF - Produção Científica 2000-2009

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Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta 1-induced apoptosis of rat hepatocytes

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