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Radiofrequency catheter ablation of ventricular tachycardia in ischemic heart disease in light of current practice : a systematic review and meta-analysis of randomized controlled trials

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dc.contributor.authorLima da Silva, Gustavo
dc.contributor.authorNunes-Ferreira, Afonso
dc.contributor.authorCortez-Dias, Nuno
dc.contributor.authorSousa, João de
dc.contributor.authorPinto, Fausto J.
dc.contributor.authorCaldeira, Daniel
dc.date.accessioned2020-09-30T14:01:36Z
dc.date.available2020-09-30T14:01:36Z
dc.date.issued2020
dc.description© Springer Science+Business Media, LLC, part of Springer Nature 2020.pt_PT
dc.description.abstractPurpose: Ventricular tachycardia (VT) is a frequent cause of mortality and morbidity in patients with ischemic heart disease (IHD). We aim to perform a systematic review and meta-analysis of randomized controlled trials (RCT) of radiofrequency catheter ablation (RCA) of VT in patients with IHD and to discuss its appropriate timing and limitations. Methods: Literature searches of MEDLINE, CENTRAL, the Cochrane Database of Systematic Reviews, Health Technology Assessment, and PsycINFO were performed in February 2020. RCTs comparing RCA vs conventional management for VT in patients with IHD and previous or planned implantable cardioverter defibrillator (ICD) were identified. Clinical outcomes included all-cause mortality, cardiovascular mortality, cardiovascular hospitalization, VT storm, recurrent VT/ventricular fibrillation (VF), appropriate ICD therapies, and appropriate ICD shocks. Using a random-effects model, relative risk (RR) and 95% confidence intervals (CI) were calculated for each outcome. Results: A total of 6 RCTs (N = 791) met inclusion criteria. RCA was associated with significantly lower VT storm (RR 0.70; CI95% 0.51 to 0.94, p = 0.02) and appropriate ICD therapies (RR 0.69; CI95% 0.54 to 0.88, p = 0.003), including appropriate ICD shocks (RR 0.66; CI95% 0.47 to 0.92, p = 0.02). There was no significant difference in all-cause or cardiovascular mortality, cardiovascular hospitalization, and recurrent VT/VF. Conclusions: Radiofrequency catheter ablation for VT in patients with IHD was associated with a reduced risk of VT storm, ICD therapies, and ICD shocks. There is a need for future carefully designed RCTs that incorporate improved RCA procedural aspects.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Interv Card Electrophysiol, 19 September 2020pt_PT
dc.identifier.doi10.1007/s10840-020-00870-3pt_PT
dc.identifier.eissn1572-8595
dc.identifier.issn1383-875X
dc.identifier.urihttp://hdl.handle.net/10451/44481
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/10840/pt_PT
dc.subjectCatheter ablationpt_PT
dc.subjectIschemic heart diseasept_PT
dc.subjectMeta-analysispt_PT
dc.subjectSystematic reviewpt_PT
dc.subjectVentricular tachycardiapt_PT
dc.titleRadiofrequency catheter ablation of ventricular tachycardia in ischemic heart disease in light of current practice : a systematic review and meta-analysis of randomized controlled trialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Interventional Cardiac Electrophysiologypt_PT
person.familyNameLima da Silva
person.familyNameNunes-Ferreira
person.familyNameCortez-Dias
person.familyNamePinto
person.familyNameCaldeira
person.givenNameGustavo
person.givenNameAfonso
person.givenNameNuno
person.givenNameFausto J.
person.givenNameDaniel
person.identifier1308889
person.identifier.ciencia-idFB15-EB01-5F40
person.identifier.ciencia-id0419-C014-BA22
person.identifier.ciencia-idD612-D3C3-6E1D
person.identifier.ciencia-idC311-AEDD-6DBB
person.identifier.ciencia-idAA19-EC35-8D01
person.identifier.orcid0000-0003-3138-8354
person.identifier.orcid0000-0002-2836-9497
person.identifier.orcid0000-0002-9244-4631
person.identifier.orcid0000-0002-8034-4529
person.identifier.orcid0000-0002-2520-5673
person.identifier.ridG-9363-2015
person.identifier.scopus-author-id7102740158
person.identifier.scopus-author-id36623384200
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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