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Cronoterapia e ritmos circadianos: timing is important in medication administration
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Resumo(s)
A Cronoterapia, um conceito emergente no campo da Farmacoterapia, remete para a alteração dos horários de administração dos fármacos, com o intuito de otimizar o tratamento e minimizar os eventuais efeitos secundários deste.
Neste trabalho, será feita uma primeira abordagem a conceitos como Cronoterapia, Cronofarmacologia, Cronofarmacocinética, Cronofarmacodinamia e ainda ao Ritmo Circadiano e aos genes associados à Cronobiologia. Serão também apresentados alguns grupos de fármacos em que tem sido estudada a Cronoterapia, como anti-hipertensores, estatinas e antineoplásicos.
O uso da Cronoterapia na utilização de fármacos tem vindo a ser cada vez mais estudado, apresentando ainda uma elevada margem de progressão. Contudo, estudos futuros deverão explorar também mais diferenças relacionas com o genoma, o género e a idade dos indivíduos, assim como outras variáveis intra e inter-individuais.
Chronotherapy, an emerging concept in the Pharmacotherapy area, refers to the modification of drugs administration time, aiming for the therapeutic optimization and the minimization of its side effects. In this work, it will be explained some of the concepts associated with Chronotherapy, like Chronopharmacology, Chronopharmacokinetics, Chronopharmacodynamics, the Circadian Rhythms and its associated genes. It will be presented some drug groups in which Chronotherapy has been investigated, like anti-hypertension drugs, statins and cytotoxic drugs. The usage of Chronotherapy has been increasingly studied, however it still has a great progression margin. Future studies should explore more the differences related to the genome, gender and age of individuals, as well as other intra and inter-individual variables.
Chronotherapy, an emerging concept in the Pharmacotherapy area, refers to the modification of drugs administration time, aiming for the therapeutic optimization and the minimization of its side effects. In this work, it will be explained some of the concepts associated with Chronotherapy, like Chronopharmacology, Chronopharmacokinetics, Chronopharmacodynamics, the Circadian Rhythms and its associated genes. It will be presented some drug groups in which Chronotherapy has been investigated, like anti-hypertension drugs, statins and cytotoxic drugs. The usage of Chronotherapy has been increasingly studied, however it still has a great progression margin. Future studies should explore more the differences related to the genome, gender and age of individuals, as well as other intra and inter-individual variables.
Descrição
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2013
Palavras-chave
Mestrado Integrado - 2013