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Publicação
Circadian clocks as modulators of metabolic comorbidity in psychiatric disorders
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Orientador(es)
Resumo(s)
Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.
Descrição
© Springer Science+Business Media New York 2015
Palavras-chave
Circadian rhythm Depression Metabolic syndrome Obesity Psychiatric disorders Reward
Contexto Educativo
Citação
Curr Psychiatry Rep. 2015 Dec;17(12):98
Editora
Springer Nature