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Structural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighbors

2021-02-26Artigo científico Acesso aberto
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dc.contributor.authorLeitão, Ana Lúcia
dc.contributor.authorEnguita, Francisco J.
dc.date.accessioned2021-03-19T16:27:00Z
dc.date.available2021-03-19T16:27:00Z
dc.date.issued2021-02-26
dc.descriptionCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative CommonsAttribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractEsters are organic compounds widely represented in cellular structures and metabolism, originated by the condensation of organic acids and alcohols. Esterification reactions are also used by chemical industries for the production of synthetic plastic polymers. Polyester plastics are an increasing source of environmental pollution due to their intrinsic stability and limited recycling efforts. Bioremediation of polyesters based on the use of specific microbial enzymes is an interesting alternative to the current methods for the valorization of used plastics. Microbial esterases are promising catalysts for the biodegradation of polyesters that can be engineered to improve their biochemical properties. In this work, we analyzed the structure-activity relationships in microbial esterases, with special focus on the recently described plastic-degrading enzymes isolated from marine microorganisms and their structural homologs. Our analysis, based on structure-alignment, molecular docking, coevolution of amino acids and surface electrostatics determined the specific characteristics of some polyester hydrolases that could be related with their efficiency in the degradation of aromatic polyesters, such as phthalates.pt_PT
dc.description.sponsorshipThis work is supported by the Portuguese Foundation for Science and Technology (FCT) under the framework of the research grant PTDC-MED-GEN-29389-2017.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt. J. Mol. Sci. 2021, 22, 2332.pt_PT
dc.identifier.doi10.3390/ijms22052332pt_PT
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttp://hdl.handle.net/10451/46931
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPTDC-MED-GEN-29389-2017pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/ijmspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolyesterpt_PT
dc.subjectEsterasept_PT
dc.subjectPlastic polymerpt_PT
dc.subjectBiodegradationpt_PT
dc.subjectdepolymerizing esterasept_PT
dc.subjectPETasept_PT
dc.titleStructural insights into carboxylic polyester-degrading enzymes and their functional depolymerizing neighborspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.citation.volume22pt_PT
person.familyNameEnguita
person.givenNameFrancisco J.
person.identifier173306
person.identifier.ciencia-idB215-8D49-3218
person.identifier.orcid0000-0002-8072-8557
person.identifier.ridA-2347-2009
person.identifier.scopus-author-id6602119231
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa101dbd4-6bf5-4546-882e-e2596eddb6b4
relation.isAuthorOfPublication.latestForDiscoverya101dbd4-6bf5-4546-882e-e2596eddb6b4

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