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A retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorder

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dc.contributor.authorNeutel, Dulce
dc.contributor.authorAlvarenga, Tathiana
dc.contributor.authorReis, Cátia
dc.contributor.authorPaiva, Teresa
dc.date.accessioned2020-07-21T11:56:07Z
dc.date.available2020-07-21T11:56:07Z
dc.date.issued2020
dc.description© 2020 Neutel D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_PT
dc.description.abstractInsomnia is a prevalent sleep disorder. We examined chronic insomnia in terms of subjective and objective measures, according to self-reported duration of disorder. 443 patients were included from a sleep clinic diagnosed with chronic insomnia (ICSD3 criteria). Patients were retrospectively evaluated in terms of medical interview, sleep questionnaires, a standard polysomnography study, and subdivided in subgroups according to disorder duration. We compared patient’s results to a control group. Insomnia and control groups were significantly different in terms of TST, SE, SOL, N1 sleep, REM sleep, REM latency and number of REM episodes (p<0.05). For the group of ≤1 year of insomnia disorder all PSG parameters were statistically different from controls, except N2% and N3%, REM latency, and number of REM episodes. In the groups of 2 to 4 years, 10 to 19 years, and ≥ 20 years of insomnia we found the same differences except for REM sleep. On the contrary, in a subgroup analysis of 5 to 9 years of insomnia disorder duration, no differences to control group were found in TST, N1 or REM sleep to control group, adjusted for age. The polysomnographic sleep profile of chronic insomnia patients is different over time. It sketches an initial attempt of compensation in initial years of insomnia, which seems to disappear in long time chronic insomnia patients, as we usually see in others neurodegenerative disorders. Future studies are needed to clarify the natural history of chronic insomnia disorder and its behaviour as a neurodegenerative disorder.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Sleep Disord Ther 9:310pt_PT
dc.identifier.doi10.35248/2167-0277.19.9.309.pt_PT
dc.identifier.issn2167-0277
dc.identifier.urihttp://hdl.handle.net/10451/44080
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherLongdom Publishingpt_PT
dc.relation.publisherversionhttps://www.longdom.org/sleep-disorders-therapy.htmlpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInsomnia disorderpt_PT
dc.subjectPolysomnographypt_PT
dc.subjectDegenerative processpt_PT
dc.titleA retrospective study suggests that chronic insomnia behaves as a neurodegenerative disorderpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.titleJournal of Sleep Disorders and Therapypt_PT
oaire.citation.volume9pt_PT
person.familyNamePeixinho Reis
person.familyNamePaiva
person.givenNameCátia Cristina
person.givenNameMaria Teresa Aguiar dos Santos
person.identifier1465255
person.identifier.ciencia-idC817-4B30-902F
person.identifier.ciencia-id7B10-224A-DB1D
person.identifier.orcid0000-0001-6585-3993
person.identifier.orcid0000-0002-7937-7841
person.identifier.scopus-author-id7005950248
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication39014fe9-c831-4a22-ae3c-e464f35592cc
relation.isAuthorOfPublicationc720c5dd-a926-4737-938d-a90e782dd837
relation.isAuthorOfPublication.latestForDiscovery39014fe9-c831-4a22-ae3c-e464f35592cc

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