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Histopathological characterization of cerebral small vessel disease in epilepsy patients with temporal lobe epilepsy submitted to surgery: a case–control study

2023Journal article Restricted access
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dc.contributor.authorCoelho, Pedro
dc.contributor.authorMadureira, João
dc.contributor.authorFranco, Ana Catarina
dc.contributor.authorPeralta, Ana
dc.contributor.authorBentes, Carla
dc.contributor.authorRainha Campos, Alexandre
dc.contributor.authorAnink, Jasper
dc.contributor.authorAronica, Eleonora
dc.contributor.authorRoque, Rafael
dc.contributor.authorPimentel, José
dc.date.accessioned2023-11-29T14:41:57Z
dc.date.available2023-11-29T14:41:57Z
dc.date.issued2023
dc.description© 2023 European Academy of Neurology.pt_PT
dc.description.abstractBackground: Cerebrovascular disease (CVD) is a major contributor to epilepsy; however, patients with epilepsy also have a significantly increased risk of stroke. The way in which epilepsy contributes to the increased risk of stroke is still uncertain and is ill-characterized in neuropathological studies. A neuropathological characterization of cerebral small vessel disease (cSVD) in patients with chronic epilepsy was performed. Methods: Thirty-three patients with refractory epilepsy and hippocampal sclerosis (HS) submitted to epilepsy surgery from a reference center were selected between 2010 and 2020 and compared with 19 autopsy controls. Five randomly selected arterioles from each patient were analyzed using a previously validated scale for cSVD. The presence of CVD disease imaging markers in pre-surgical brain magnetic resonance imaging (MRI) was studied. Results: There were no differences in age (43.8 vs. 41.6 years; p = 0.547) or gender distribution (female gender 60.6% vs. male gender 52.6%; p = 0.575) between groups. Most CVD findings in brain MRI were mild. Patients had a mean time between the epilepsy onset and surgery of 26 ± 14.7 years and were medicated with a median number of three antiseizure medication (ASMs) [IQR 2-3]. Patients had higher median scores in arteriolosclerosis (3 vs. 1; p < 0.0001), microhemorrhages (4 vs. 1; p < 0.0001) and total score value (12 vs. 8.9; p = 0.031) in comparison with controls. No correlation was found between age, number of years until surgery, number of ASMs or cumulative defined daily dosage of ASM. Conclusion: The present study provides evidence supporting the increased burden of cSVD in the neuropathological samples of patients with chronic epilepsy.pt_PT
dc.description.sponsorshipThe work was supported by the following grants: European Union's Horizon 2020 Research and Innovation Program under grant agreement No. 952455: EpiEpiNet; 2022 EAN Scientific Research Fellowship; and Bolsa Científica LPCE 2021 from Liga Portuguesa Contra Epilepsia.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Neurol. 2023 Oct;30(10):2999-3007pt_PT
dc.identifier.doi10.1111/ene.15963pt_PT
dc.identifier.eissn1468-1331
dc.identifier.issn1351-5101
dc.identifier.urihttp://hdl.handle.net/10451/60994
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relationEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/14681331pt_PT
dc.subjectAtherosclerosispt_PT
dc.subjectCerebral small vessel diseasept_PT
dc.subjectEpilepsypt_PT
dc.subjectHippocampal sclerosispt_PT
dc.subjectNeuropathologypt_PT
dc.subjectStrokept_PT
dc.titleHistopathological characterization of cerebral small vessel disease in epilepsy patients with temporal lobe epilepsy submitted to surgery: a case–control studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpileptogenesis and Epilepsy Network: from genes, synapses and circuits to pave the way for novel drugs and strategies
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/952455/EU
oaire.citation.endPage3007pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage2999pt_PT
oaire.citation.titleEuropean Journal of Neurologypt_PT
oaire.citation.volume30pt_PT
oaire.fundingStreamH2020
person.familyNameCoelho
person.familyNameFranco
person.familyNamePeralta
person.familyNameBentes
person.familyNameRainha Campos
person.familyNameValente Fidalgo Ramos Roque
person.familyNamePimentel
person.givenNamePedro
person.givenNameAna Catarina
person.givenNameAna Rita
person.givenNameCarla
person.givenNameAlexandre
person.givenNameRafael
person.givenNameJosé
person.identifier.ciencia-id901D-0A93-5E80
person.identifier.ciencia-id9313-9F25-E425
person.identifier.ciencia-id1D1D-D037-54D8
person.identifier.ciencia-id7D1C-D5DD-C579
person.identifier.ciencia-id2910-471A-8664
person.identifier.ciencia-id051B-EAEE-FD29
person.identifier.orcid0000-0003-0515-9187
person.identifier.orcid0000-0002-4371-9272
person.identifier.orcid0000-0001-9449-431X
person.identifier.orcid0000-0003-2399-7678
person.identifier.orcid0000-0003-4781-4717
person.identifier.orcid0000-0002-6101-6650
person.identifier.scopus-author-id6603395191
person.identifier.scopus-author-id7006096045
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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