Logo do repositório
 
Publicação

Efficacy, safety, and sample quality of ultrasound‐guided synovial needle biopsy in clinical practice and research : a prospective observational study

2020Artigo científico Acesso restrito
Ver registo simples
dc.contributor.authorRomão, Vasco C.
dc.contributor.authorPolido Pereira, Joaquim
dc.contributor.authorBarros, Rita
dc.contributor.authorLuis, Rita
dc.contributor.authorVidal, Bruno
dc.contributor.authorVieira De Sousa, Elsa Cristina
dc.contributor.authorVitorino, Emília
dc.contributor.authorHumby, Frances
dc.contributor.authorKelly, Stephen
dc.contributor.authorPitzalis, Costantino
dc.contributor.authorSaraiva, Fernando
dc.contributor.authorFonseca, João Eurico
dc.date.accessioned2021-03-04T16:59:38Z
dc.date.available2021-03-04T16:59:38Z
dc.date.issued2020
dc.description© 2019, American College of Rheumatology.pt_PT
dc.description.abstractObjective: To study the efficacy, tolerability, safety, and sampling variation of ultrasound (US)-guided synovial biopsies performed in clinical practice and research. Methods: We included all patients who had a US-guided synovial needle biopsy from November 2013 to January 2018. Patients were evaluated for procedure safety and tolerability. Usefulness of synovial biopsy was considered based on contribution for achieving the proposed aims. We analyzed samples for presence and quality of synovial tissue, synovitis score/grade, and pathotype. Variation across patients, samples, section levels, and sampling order was assessed. Results: A total of 64 US-guided synovial biopsies were performed (n = 52 in clinical practice, n = 12 in research). Patient tolerability (70% no/mild discomfort) was remarkably high. There was no significant aggravation of symptoms or US synovitis in the biopsied joint. Procedures were overall safe, with few minor, 2 moderate, and no major adverse events. Usefulness of US-guided synovial biopsies was high, both in clinical practice (37% direct diagnostic impact, 100% positive/95% negative predictive values for infection) and in research (92% success). Synovial tissue was retrieved in 88% of biopsies, with a median of 75% gradable samples. There was significant variation in sample quality and synovitis features across patients and samples, but not between different section levels. Samples collected later in the procedure had a lower frequency of synovial tissue and were poorly concordant in pathotype with those collected earlier. Conclusion: US-guided synovial needle biopsy is an effective, safe, and well-tolerated means to collect good quality synovial tissue for clinical and research purposes. Samples collected for different aims should be retrieved in parallel, rather than sequentially.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia. Grant Numbers: LISBOA‐01‐0145‐FEDER‐007391, SFRH/SINTD/95030/2013pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArthritis Care Res (Hoboken). 2020 Oct;72(10):1497-1505pt_PT
dc.identifier.doi10.1002/acr.24050pt_PT
dc.identifier.eissn2151-4658
dc.identifier.issn2151-464X
dc.identifier.urihttp://hdl.handle.net/10451/46660
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons, Inc.pt_PT
dc.relationLISBOA‐01‐0145‐FEDER‐007391pt_PT
dc.relationSYNOVIAL PATHOBIOLOGY AND PATIENT STRATIFICATION IN RHEUMATOID ARTHRITIS
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/21514658pt_PT
dc.titleEfficacy, safety, and sample quality of ultrasound‐guided synovial needle biopsy in clinical practice and research : a prospective observational studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/SINTD/95030/2013
oaire.awardTitleSYNOVIAL PATHOBIOLOGY AND PATIENT STRATIFICATION IN RHEUMATOID ARTHRITIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FSINTD%2F95030%2F2013/PT
oaire.citation.endPage1505pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1497pt_PT
oaire.citation.titleArthritis Care & Researchpt_PT
oaire.citation.volume72pt_PT
person.familyNameC Romão
person.familyNamePolido Pereira
person.familyNameLuis
person.familyNameCosta Vidal
person.familyNameVieira de Sousa
person.familyNameFonseca
person.givenNameVasco
person.givenNameJoaquim
person.givenNameRita
person.givenNameBruno Miguel
person.givenNameElsa Cristina
person.givenNameJoão
person.identifier490119
person.identifier676523
person.identifier.ciencia-id771D-0A5C-626B
person.identifier.ciencia-id9812-232A-B282
person.identifier.ciencia-idA715-BDEB-7BA6
person.identifier.ciencia-id251C-3CD5-FB69
person.identifier.ciencia-id1519-509A-8B89
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0002-5603-9436
person.identifier.orcid0000-0002-7188-8516
person.identifier.orcid0000-0002-2187-8213
person.identifier.orcid0000-0003-2906-4705
person.identifier.orcid0000-0002-7170-8802
person.identifier.orcid0000-0003-1432-3671
person.identifier.ridO-8224-2014
person.identifier.scopus-author-id55989452300
person.identifier.scopus-author-id7101983519
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione7e94139-add7-4a3b-b138-fb1d1a656b0e
relation.isAuthorOfPublication757607f2-5ab2-4d9e-a968-ce37a7b9113c
relation.isAuthorOfPublication086ac481-cf5f-4e6b-9614-b0f8e2e98418
relation.isAuthorOfPublication2dba0a1c-2d16-4430-9505-5ac8369b5c86
relation.isAuthorOfPublication8b9873ad-2667-48e6-aece-a73dec6a8296
relation.isAuthorOfPublication1772dc12-7c55-4c76-ae2d-c23270172480
relation.isAuthorOfPublication.latestForDiscovery8b9873ad-2667-48e6-aece-a73dec6a8296
relation.isProjectOfPublication19261111-c899-4b70-b891-50aab0ec00c4
relation.isProjectOfPublication.latestForDiscovery19261111-c899-4b70-b891-50aab0ec00c4

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
Efficacy_safety.pdf
Tamanho:
612.01 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IMM - Artigos em Revistas Internacionais
FM-CUR-Artigos em Revistas Internacionais