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Phylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwide

2022Journal article Open access
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dc.contributor.authorMarcelino, Rute
dc.contributor.authorEzeonwumelu, Ifeanyi Jude
dc.contributor.authorJaneiro, André
dc.contributor.authorMimoso, Paula
dc.contributor.authorMatos, Sónia
dc.contributor.authorBriz, Veronica
dc.contributor.authorPimentel, Victor
dc.contributor.authorPingarilho, Marta
dc.contributor.authorMarinho, Rui
dc.contributor.authorMaria Marcelino, José
dc.contributor.authorTaveira, Nuno
dc.contributor.authorAbecasis, Ana
dc.date.accessioned2023-01-05T14:04:41Z
dc.date.available2023-01-05T14:04:41Z
dc.date.issued2022
dc.descriptionCopyright: © 2022 Marcelino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_PT
dc.description.abstractIn Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (n = 32, 24.6%). Spatio-temporal evolutionary dynamics was reconstructed in BEAST using a Bayesian Markov Chain Monte Carlo method, with a GTR nucleotide substitution model, an uncorrelated lognormal relaxed molecular clock model, a Bayesian skyline plot, and a continuous diffusion model. HBV subgenotype D4 was the first to be introduced in Portugal around 1857 (HPD 95% 1699-1931) followed by D3 and A2 a few decades later. HBV genotype E and subgenotype A1 were introduced in Portugal later, almost simultaneously. Our results indicate a very important role of Portugal in the exportation of subgenotypes D4 and A2 to Brazil and Cape Verde, respectively, in the beginning of the XX century. This work clarifies the epidemiological history of HBV in Portugal and provides new insights in the early and global epidemic history of this virus.pt_PT
dc.description.sponsorshipThis work was performed in the context of Rute Marcelino PhD study, whose student’s fellowship (SFRH/BD/99507/2014) was supported by the Portuguese Agency for Scientific Research, Fundação para a Ciência e Tecnologia (FCT), POCH program, Portugal 2020, and European Union/Social European Fund (FSE). This work was also supported by FCT through funds of AA's projects GHTM-UID/Multi/04413/2013 and GHTM-UID/04413/2020 and also NT's projects UIDB/04138/2020 and UIDP/04138/2020.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS One. 2022 Dec 22;17(12):e0276618pt_PT
dc.identifier.doi10.1371/journal.pone.0276618pt_PT
dc.identifier.eissn1932-6203
dc.identifier.urihttp://hdl.handle.net/10451/55661
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationGHTM-UID/Multi/04413/2013pt_PT
dc.relationCélulas B de memória: uma nova abordagem na identificação de potenciais domínios neutralizantes envolvidos na eliminação do vírus da Hepatite C VHC.
dc.relationResearch Institute for Medicines
dc.relationResearch Institute for Medicines
dc.relation.publisherversionhttps://journals.plos.org/plosone/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titlePhylogeography of hepatitis B virus: the role of Portugal in the early dissemination of HBV worldwidept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCélulas B de memória: uma nova abordagem na identificação de potenciais domínios neutralizantes envolvidos na eliminação do vírus da Hepatite C VHC.
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleResearch Institute for Medicines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F99507%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT
oaire.citation.issue12pt_PT
oaire.citation.titlePLOS ONEpt_PT
oaire.citation.volume17pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCarvalho Antunes Marcelino
person.familyNameJaneiro
person.familyNameMarinho
person.familyNameTaveira
person.givenNameRute Alexandra
person.givenNameAndré
person.givenNameRui
person.givenNameNuno
person.identifier.ciencia-idA417-7162-733D
person.identifier.ciencia-id531A-BB6A-AA45
person.identifier.ciencia-id7111-3383-A926
person.identifier.orcid0000-0002-4535-9725
person.identifier.orcid0000-0002-9267-2079
person.identifier.orcid0000-0003-1327-3537
person.identifier.orcid0000-0003-0176-5585
person.identifier.scopus-author-id7005027284
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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