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Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae

2023Journal article Open access
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dc.contributor.authorMendes, Gabriel
dc.contributor.authorSantos, Maria Leonor
dc.contributor.authorRamalho, João Francisco
dc.contributor.authorDuarte, Aida
dc.contributor.authorCaneiras, Catia
dc.date.accessioned2023-12-05T12:39:25Z
dc.date.available2023-12-05T12:39:25Z
dc.date.issued2023
dc.descriptionCopyright © 2023 Mendes, Santos, Ramalho, Duarte and Caneiras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractHypervirulence and carbapenem-resistant have emerged as two distinct evolutionary pathotypes of Klebsiella pneumoniae, with both reaching their epidemic success and posing a great threat to public health. However, as the boundaries separating these two pathotypes fade, we assist a worrisome convergence in certain high-risk clones, causing hospital outbreaks and challenging every therapeutic option available. To better understand the basic biology of these pathogens, this review aimed to describe the virulence factors and their distribution worldwide among carbapenem-resistant highly virulent or hypervirulent K. pneumoniae strains, as well as to understand the interplay of these virulence strains with the carbapenemase produced and the sequence type of such strains. As we witness a shift in healthcare settings where carbapenemresistant highly virulent or hypervirulent K. pneumoniae are beginning to emerge and replace classical K. pneumoniae strains, a better understanding of these strains is urgently needed for immediate and appropriate response.pt_PT
dc.description.sponsorshipThis research was partially funded by Fundação para a Ciência e a Tecnologia (FCT), under grant numbers UIDB/04295/2020 and UIDP/04295/2020. Moreover, CC acknowledges the funding provided by the “Research Award in Healthcare Associated Infections” granted by Escola Superior de Saúde Norte da Cruz Vermelha Portuguesa (2019) and by “BInov award,” an innovation award granted by the Southern Regional Section and Autonomous Regions of the Portuguese Pharmaceutical Society (2021). GM was supported by Fundação para a Ciência e Tecnologia (FCT), Portugal, through a Ph.D. Research Studentship Contract (Contrato de Bolsa de Investigação para Doutoramento 2020.07736.BD).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront. Microbiol. 14:1325077pt_PT
dc.identifier.doi10.3389/fmicb.2023.1325077pt_PT
dc.identifier.eissn1664-302X
dc.identifier.urihttp://hdl.handle.net/10451/61141
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationEnvironmental Health Institute
dc.relationEnvironmental Health Institute
dc.relationInterplay between resistance and virulence markers in Enterobacteriales carbapenemase producers
dc.relation.publisherversionhttps://www.frontiersin.org/journals/microbiologypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectKlebsiella pneumoniaept_PT
dc.subjectSiderophorespt_PT
dc.subjectHigh-risk clonespt_PT
dc.subjectST11pt_PT
dc.subjectST23pt_PT
dc.subjectST13pt_PT
dc.subjectKPC-variantspt_PT
dc.subjectTreatmentpt_PT
dc.titleVirulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniaept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEnvironmental Health Institute
oaire.awardTitleEnvironmental Health Institute
oaire.awardTitleInterplay between resistance and virulence markers in Enterobacteriales carbapenemase producers
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04295%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04295%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.07736.BD/PT
oaire.citation.titleFrontiers in Microbiologypt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameFernandes Mendes
person.familyNameRainha Miranda Antunes dos Santos
person.familyNameMarmelo Ramalho
person.familyNameDuarte
person.familyNameCaneiras
person.givenNameGabriel
person.givenNameMaria Leonor
person.givenNameJoão Francisco
person.givenNameAida
person.givenNameCatia
person.identifier2030815
person.identifier2524696
person.identifier.ciencia-id991D-C028-6746
person.identifier.ciencia-id6111-7E61-09A0
person.identifier.ciencia-idA613-F3D0-4C82
person.identifier.ciencia-idD517-F4DB-17C1
person.identifier.ciencia-id5217-449F-3B4F
person.identifier.orcid0000-0003-2610-8522
person.identifier.orcid0000-0001-9454-6220
person.identifier.orcid0000-0002-2312-225X
person.identifier.orcid0000-0002-0616-4650
person.identifier.orcid0000-0002-3735-8554
person.identifier.ridM-5272-2013
person.identifier.scopus-author-id35495748300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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