Diazo-free C-H insertion of acylsilanes towards new cyclic silanes.

Financiador

Organização

Publicações

Publication . Vale, João R.; Fortunato, Milene A. G.; Andrade, Késsia H. S.; Rocha, Ângelo M. R.; Afonso, Carlos; Siopa, Filipa

(−)-Agelastatin A was synthetized employing a flow photorearrangement of a pyridinium salt, constructing in one step the cyclopentene core possessing the desired functionalities and relative configurations. A flow enzymatic kinetic resolution of the resulting bicyclic vinyl aziridine delivered the enantiopure precursor to the natural product. This total synthesis required the use of a single protective group. Two novel agelastatin N3-derivatives were synthesized and their cytotoxicity evaluated against a series of cancer cell lines, which corroborated the importance of unsubstituted N3 in the biological activity of (−)-agelastatin A.

2023-06Artigo científico

Acesso aberto

Ver mais

Entidade financiadora

Fundação para a Ciência e a Tecnologia

Número da atribuição

SFRH/BD/120119/2016