Understanding T cell receptor (TCR) signalling requirements for thymic gamma/delta cell development; are gamma/delta cells selected through their TCR?.

Funder

Organizational Unit

Publications

Thymic determinants of γδ T cell differentiation

Publication . Muñoz-Ruiz, Miguel; Sumaria, Nital; Pennington, Daniel J.; Silva-Santos, Bruno

γd T cells have emerged as major sources of the proinflammatory cytokines interleukin-17 (IL-17) and interferon-γ (IFNγ) in multiple models of infection, cancer and autoimmune disease. However, unlike their αβ T cell counterparts that require peripheral activation for effector cell differentiation, γδ T cells instead can be 'developmentally programmed' in the thymus to generate discrete γδ T cell effector subsets with distinctive molecular signatures. Nonetheless, recent studies have presented conflicting viewpoints on the signals involved in thymic γδ T cell development and differentiation, namely on the role of both T cell receptor (TCR)-dependent and TCR-independent factors. Here we review the current data and the ongoing controversies.

2017Journal article

Restricted access