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Projeto de investigação
Differentiation of pro-inflammatory T cell subsets in vivo
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Publicações
Cross-regulation between cytokine and microRNA pathways in T cells
Publication . Amado, Tiago; Schmolka, Nina; Metwally, Hozaifa; Silva-Santos, Bruno; Gomes, Anita Q.
microRNA (miRNA) mediated regulation of protein expression has emerged as an important mechanism in T-cell physiology, from development and survival to activation, proliferation, and differentiation. One of the major classes of proteins involved in these processes are cytokines, which are both key input signals and major products of T-cell function. Here, we summarize the current data on the molecular cross-talk between cytokines and miRNAs: how cytokines regulate miRNA expression, and how specific miRNAs control cytokine production in T cells. We also describe the inflammatory consequences of deregulating the miRNA/cytokine axis in mice and humans. We believe this topical area will have key implications for immune modulation and treatment of autoimmune pathology.
The emerging protumor role of γδ T lymphocytes: implications for cancer immunotherapy
Publication . Rei, Margarida; Pennington, Daniel J.; Silva-Santos, Bruno
Tumor-infiltrating lymphocytes are key mediators of tumor immune surveillance and are important prognostic indicators in cancer progression. Among the various lymphocyte subsets implicated in protection against cancer are γδ T lymphocytes, which can kill tumor cells and secrete potent antitumor cytokines. By contrast, recent reports have revealed an unexpected series of protumor functions of γδ T cells in mouse models and human patients. In particular, specific γδ T-cell subsets are capable of recruiting immunosuppressive myeloid populations, inhibiting antitumor responses, and enhancing angiogenesis, thus promoting cancer progression. A common mediator of such functions appears to be the cytokine IL17, whose pathogenic effects can override the antitumor immune response orchestrated by IFNγ. Here, we review these studies and discuss their implications for the manipulation of γδ T cells in cancer immunotherapy.
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Entidade financiadora
European Commission
Programa de financiamento
FP7
Número da atribuição
260352