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  • O teatro da Rua dos Condes : 1738- 1882
    Publication . Ferreira, Licínia Rodrigues; Camões, José António Camilo Guerreiro
    O Teatro da Rua dos Condes foi um dos principais espaços teatrais públicos em Portugal nos séculos XVIII e XIX. Alguns dos acontecimentos mais importantes na história do espetáculo em Portugal estão ligados a este espaço. O presente trabalho propõe uma história do Teatro da Rua dos Condes, dividida em cinco períodos, compreendidos entre 1738 e 1882. O primeiro período vai de 1738 até ao terramoto de 1755, e é marcado pelo êxito da ópera italiana, prevalecendo os textos de Pietro Metastasio. Neste ponto, enquadra-se o espaço na cidade de Lisboa e dá-se conta dos interesses que levaram à fundação do Teatro da Rua dos Condes. O segundo período, decorrendo do pós-terramoto até ao final do século XVIII, corresponde a um desenvolvimento da gestão comercial do espetáculo, exercida por vários empresários, a nível particular, e, a nível público, por uma sociedade. Continua a prevalecer a ópera, mas sucedem-se vários outros géneros, desde a comédia aos dançarinos de corda. O terceiro período da história do Teatro da Rua dos Condes, já no século XIX, contemporâneo das invasões francesas e das lutas liberais, é marcado pelos factos políticos e pela gestão de dois diretores: António José de Paula e Manuel Batista de Paula. É o tempo dos dramas sentimentais e das farsas, e fica igualmente marcado pela sociedade com o Teatro de São Carlos. O quarto período corresponde à época dourada do Teatro da Rua dos Condes, quando foi palco da renovação do teatro português, sob influência dos ideais estéticos do romantismo e dos ideais políticos do liberalismo. O drama histórico, o melodrama e o vaudeville, de influência francesa, imperaram na década de 1835 a 1846. Finalmente, no quinto período, de 1852 até à demolição do edifício, em 1882, o Condes foi um teatro popular, do gosto das plateias, oferecendo sobretudo comédias e peças de grande efeito, onde os maquinismos e as coplas eram indispensáveis. Gerido por uma associação, soube reencontrar o seu caminho entre as camadas populares da cidade de Lisboa. Esta história é feita, portanto, dos espetáculos e seus agentes, que ao longo de quase século e meio deram vida ao Teatro da Rua dos Condes.
    2019-11-05Doctoral thesis Open access Show more
  • Clinical predictors and prognostic impact of recovery of wall motion abnormalities in Takotsubo syndrome : results from the international Takotsubo registry
    Publication . Jurisic, Stjepan; Gili, Sebastiano; Cammann, Victoria L.; Kato, Ken; Szawan, Konrad A.; D'Ascenzo, Fabrizio; Jaguszewski, Milosz; Bossone, Eduardo; Citro, Rodolfo; Sarcon, Annahita; Napp, L. Christian; Franke, Jennifer; Noutsias, Michel; Knorr, Maike; Heiner, Susanne; Burgdorf, Christof; Koenig, Wolfgang; Pott, Alexander; Kherad, Behrouz; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Cuneo, Alessandro; Jacobshagen, Claudius; Karakas, Mahir; Meyer, Philippe; Arroja, Jose David; Banning, Adrian; Cuculi, Florim; Kobza, Richard; Fischer, Thomas A.; Vasankari, Tuija; Airaksinen, K E Juhani; Dworakowski, Rafal; Kaiser, Christoph; Osswald, Stefan; Galiuto, Leonarda; Dichtl, Wolfgang; Chan, Christina; Bridgman, Paul; Beug, Daniel; Delmas, Clément; Lairez, Olivier; Kozel, Martin; Tousek, Petr; Winchester, David E; Gilyarova, Ekaterina; Shilova, Alexandra; Gilyarov, Mikhail; El-Battrawy, Ibrahim; Akin, Ibrahim; Galuszka, Jan; Ukena, Christian; Poglajen, Gregor; Paolini, Carla; Bilato, Claudio; Carrilho-Ferreira, Pedro; Pinto, Fausto J.; Opolski, Grzegorz; MacCarthy, Philip; Kobayashi, Yoshio; Prasad, Abhiram; Rihal, Charanjit S.; Widimský, Petr; Horowitz, John D.; Di Mario, Carlo; Crea, Filippo; Tschöpe, Carsten; Pieske, Burkert M.; Hasenfuß, Gerd; Rottbauer, Wolfgang; Braun-Dullaeus, Ruediger C.; Felix, Stephan B.; Borggrefe, Martin; Thiele, Holger; Bauersachs, Johann; Katus, Hugo A.; Schunkert, Heribert; Münzel, Thomas; Böhm, Michael; Bax, Jeroen J.; Lüscher, Thomas F.; Ruschitzka, Frank; Ghadri, Jelena R; Templin, Christian
    Background: Left ventricular (LV) recovery in takotsubo syndrome (TTS) occurs over a wide‐ranging interval, varying from hours to weeks. We sought to investigate the clinical predictors and prognostic impact of recovery time for TTS patients. Methods and Results: TTS patients from the International Takotsubo Registry were included in this study. Cut‐off for early LV recovery was determined to be 10 days after the acute event. Multivariable logistic regression was used to assess factors associated with the absence of early recovery. In‐hospital outcomes and 1‐year mortality were compared for patients with versus without early recovery. We analyzed 406 patients with comprehensive and serial imaging data regarding time to recovery. Of these, 191 (47.0%) had early LV recovery and 215 (53.0%) demonstrated late LV improvement. Patients without early recovery were more often male (12.6% versus 5.2%; P=0.011) and presented more frequently with typical TTS (76.3% versus 67.0%, P=0.040). Cardiac and inflammatory markers were higher in patients without early recovery than in those with early recovery. Patients without early recovery showed unfavorable 1‐year outcome compared with patients with early recovery (P=0.003). On multiple logistic regression, male sex, LV ejection fraction <45%, and acute neurologic disorders were associated with the absence of early recovery. Conclusions: TTS patients without early LV recovery have different clinical characteristics and less favorable 1‐year outcome compared with patients with early recovery. The factors associated with the absence of early recovery included male sex, reduced LV ejection fraction, and acute neurologic events.
    2019-11-05Journal article Open access Show more
  • Feline hemoplasmas : evaluation of specific antibodies and the molecular and cytological diagnostic
    Publication . Catarino, Patrícia Pacheco Nobre Pina; Duarte, Ana Isabel Simões Pereira; Meireles, José Augusto Farraia e Silva
    Mycoplasma haemofelis, Candidatus Mycoplasma haemominutum and Candidatus Mycoplasma turicensis are three hemoplasmas responsible for feline hemolytic anemias. The diagnosis of the infection can be performed by observation of the agents on blood smears or by their identification and quantification using PCR techniques, presently considered the gold standard method. A recombinant antigen for Mhf (rDnaK) has been identified, characterized, produced and then successfully applied in Western blot and ELISA assays (rELISA) to detect antibodies in samples from experimentally induced infections. To evaluate this application under field conditions, this rELISA was used in samples collected from naturally infected cats, in parallel with quantitative PCR and cytologic examination. Within the scope of the TNR program implemented by the Lisbon City Council, blood samples were collected from 104 cats. After sample collection, blood was immediately used to prepare blood smears which were then stained with Giemsa (Parasitology Lab, FMV/Lisbon University). The remaining blood was split into two aliquots: 1 – Plasma separation, shipped to Vetsuisse Faculty, Zurich University, for antibody testing with rELISA; 2 – Total DNA extraction for identification and quantification of the three species of hemoplasma using qPCR (Virology Lab, FMV/Lisbon University). Out of 22.1% (N=23) samples where the microorganism was identified by qPCR, mycoplasmas were also identified on the blood smears of 15.4% (N=16). 4.8% (N=5) of samples tested as seropositive and 2.9% (N=3) revealed bordeline results. From 77.9% (N=81) of samples that were negative by qPCR, only 44.2% (N=46) were also negative on cytologic examination. 60.6% (N=63) of samples were considered seronegative and 6.7% (N=7) were borderline. Sensitivity for cytology was 69.6% and specificity was 56.8%. Sensibility of rELISA was 25% and its specificity was 85.1%. Cohen’s Kappa (k) was calculated to assess agreement between PCR-Cytology (k=0.1836) and PCR-rELISA (k=0.1093). Given the low agreement, PCR was found to be the most appropriate diagnostic method. Further studies are necessary to characterize the response of the immune system and the role of different antigens in these infections in order to improve the suitability of rELISA in a clinical setting
    2019-11-05Master thesis Open access Show more