FM - Artigos em Revistas Internacionais
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- Iodometric and colorimetric methods for the estimation of calcium in serum based on the use of an improved permanganate solutionPublication . Loureiro, João Avelar Maia de, 1901-1949; Janz, Guilherme Jorge, 1913-1999The present paper is limited to a discussion of the principles of an iodometric and a colorimetric method, which are both more reliable than the usual titration, and to showing that their results agree closely with those obtained by the Clark & Collip (1921) method, when applied to 2 ml. samples of serum.
- Endemic pellagra in northern PortugalPublication . Monteiro, A. Moura; Coutinho, Herculano; Janz, Guilherme Jorge, 1913-1999; Loureiro, João Avelar Maia de, 1901-1949In Portugal endemic pellagra has been known for many years. Since 1896 about twenty-five papers have dealt with the subject, the most valuable being those of Pereira da Silva (1905) and Manuel Ferreira (1927). No country-wide statistics of the prevalence are available, but all authors agree that pellagra is widespread in all the maize-growing districts of Portugal. The purpose of the present work was to study the disease, using some of the recent methods for the appraisal of nutritional status.
- An approach to interpretation and classification of sinusoidal fetal heart rate patternsPublication . Graça, Luis M.; Cardoso, Conceição G.; Calhaz-Jorge, CarlosSinusoidal fetal heart rate (SHR) records were obtained in 8 cases, either antepartum (3 cases of fetal Rh disease) or intrapartum (one case with an acute episode of fetomaternal transfusion as possible cause, 2 after meperidine administration to the mother and 2 others without attributable causes). Characteristics of both SHR patterns and related clinical pictures are described and compared to similar cases published elsewhere. The possible underlying mechanisms of SHR are discussed. Two different profiles of SHR patterns (smooth and jagged waveforms) are characterized and correlated with their most usual clinical backgrounds and prognostic significance. A classification of SHR into 2 main types is proposed, with clinical use in mind.
- The diagnostic significance of periportal hepatic necrosis and inflammationPublication . Baptista, A.; Bianchi, L.; De Groote, J.; Desmet, V. J.; Ishak, K. G.; Korb, G.; MacSween, R. N.; Popper, H.; Poulsen, H.; Scheuer, P. J.In this review the several types of cell damage and cell death which may be found in liver biopsy specimens are defined. We describe the different processes which occur at the portal/parenchymal or septal/parenchymal interface, viz. periportal spillover, periportal hepatitis, classic or lymphocytic piecemeal necrosis and biliary piecemeal necrosis. The diagnostic implications of these lesions in relation to the clinicopathological diagnosis and prognosis in various liver diseases are discussed.
- Computer education of undergraduate medical students : a 2-year experiencePublication . Oliveira, A. Gouveia; Melo, F. Galvão deComputer literacy will become a necessity for doctors in the near future, as computer applications for clinical medicine are gradually developed and successfully implemented in the medical environment. Two years ago we began an optional course on computer systems for first-year medical students, as part of the biostatistics course at the University of Lisbon. The results of this experience show that computer education should be well adapted to the needs of students, and educators must continuously evaluate the students' reaction and anticipate the need for sudden changes in the course structure, which are often necessary to capture students' attention.
- Agranulocytosis and liver damage associated with pyrazinobutazone with evidence for an immunological mechanismPublication . Maria, Vasco A.; Silva, J. A. da; Victorino, Rui M.Agranulocytosis and liver injury is described in a patient with Reiter's syndrome of 3 years duration who received pyrazinobutazone for 6 weeks before the development of the clinical picture reported. Other causes of agranulocytosis and hepatic damage were excluded and a lymphocyte transformation test to the drug revealed significant lymphocyte proliferation in response to the drug. This suggests a hypersensitivity reaction as the mechanism for this previously unrecognized association of adverse effects to pyrazinobutazone.
- Acute effects of maternal cigarette smoking on fetal heart rate and fetal body movements felt by the motherPublication . Graça, Luís M.; Cardoso, Conceição G.; Clode, Nuno; Calhaz-Jorge, CarlosAcute effects of maternal cigarette smoking on fetal heart rate (FHR) and fetal body movements felt by the mother (FM) were studied in 51 pregnant volunteers. Thirty four were chronic smokers (6 or more cigarettes per day, with an average of 14 cigarettes/day) and 17 were sporadic smokers (1 to 5 cigarettes per day, with an averaged of 3 cigarettes/day). In both groups the number of FM, fetal reactivity and short-term FHR variability decreased significantly in the 20 minutes following cigarette smoking; a sustained FHR rise of 10 or more beats/min was also found after the cigarette in more than 50% of the cases in the 2 groups. No statistically significant differences were found among the 2 groups when the post-cigarette data were compared. We conclude that maternal cigarette smoking produces important acute effects upon FM and FHR regardless the average daily number of cigarettes smoked by the mother.
- Inhibition of lymphocyte proliferation induced in vitro by microbial antigens in HIV-infected subjectsPublication . Maria, Vasco; Pinto, Lígia; Victorino, RuiIn the course of a study of lymphocyte responses to microbial antigens in HIV-infected patients, we detected a previously unrecognized phenomenon of inhibition of lymphocyte baseline proliferation, induced by the presence of tetanus toxoid and Escherichia coli in the cultures. The effects of tetanus toxoid and Escherichia coli on lymphocyte proliferation in vitro were assessed by comparing the 3H-thymidine uptake by lymphocytes cultured without stimulant with the uptake of lymphocytes cultured in the presence of the antigens. Twenty-six patients with HIV infection (20 asymptomatic/persistent generalized lymphadenopathy, 2 AIDS-related complex, 4 AIDS) were investigated and the controls were 33 healthy individuals without evidence of HIV infection. Eight out of 22 asymptomatic/PGL and ARC patients progressed to full-blown AIDS in the mean follow-up of 26 months. The inhibition of proliferation was considered to be significant when the uptake of 3H-thymidine was reduced by 20% in the presence of the antigens. Using these criteria, 50% of the patients studied with tetanus toxoid and 36% of those studied with E. coli had evidence of the inhibitory phenomenon. Seven of the eight patients who developed AIDS during the observation period had the inhibitory phenomenon. In the group of patients without the inhibitory signs only one evolved to AIDS during the follow-up. The possibility of this phenomenon being related to an induction of suppressor cell activity by the antigens is discussed.
- Coffin-Siris syndromePublication . Levy, Pilar Quinhones; Baraitser, MichaelIn 1970 Coffin and Siris described three unrelated female children with severe mental and developmental retardation, sparse scalp hair, and coarse appearing facies with bushy eyebrows, a wide mouth, and thick lips. There were, in addition, lax joints and brachydactyly of the fifth digits of both hands and feet with absence of the nails and terminal phalanges. To our knowledge, there have been 31 cases of this condition reported and these are reviewed in the present paper with the addition of two new cases.
- Longitudinal comparative study on the influence of computers on reporting of clinical dataPublication . Oliveira, A. Gouveia; Raposo, V. D.; Salgado, N. C.; Almeida, I.; Leitão, C. Nobre; de Melo, F. GalvãoThe impact of the clinical database system SISCOPE on medical services was evaluated and objective data compiled on the quality of information recording and reporting using a fully structured data entry system compared to traditional free text reporting. 1565 upper endoscopy reports produced with SISCOPE over a period of 12 months were assessed for completeness and compared to 152 and 208 free text reports done 4 months before and 1 month after the study period, respectively. Data on four common gastrointestinal findings (esophageal varices, ulcers, polyps and tumors) were evaluated. Physicians' compliance with the new system was good, as reflected by a constant level of quality of reporting over time, although a very slight decline in the ratio of computer generated reports to the total number of examinations was noted. Structured reports had an 18% missing data rate and contained 60% more relevant information than free text reports, which had a 48% missing data rate. No educational effect of the system was seen as missing data rates returned to pre-computerization levels just one month after the end of the study. It is concluded that menu-driven structured data entry systems result in production of far superior reports as compared to free text systems, probably due to their reminder effect.