Browsing by Author "Valdeira, ML"
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- Antiviral activity of terpenoids against Herpes simples virusesPublication . Duarte, N; Antunes, N; Ramalhete, C; Valdeira, ML; Abreu, P; Ferreira, MJ
- Catechols from abietic acidPublication . Gigante, B; Santos, C; Silva, AM; Curto, MJM; Nascimento, MSJ; Pinto, E; Pedro, M; Cerqueira, F; Pinto, MM; Duarte, MP; Laires, A; Rueff, J; Goncalves, J; Pegado, MI; Valdeira, MLCatechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant activity, as well as anticancer and antiviral properties. From all the synthetic catechols tested compound 2 showed the best activities, stronger than carnosic acid. (C) 2003 Elsevier Science Ltd. All rights reserved.
- Synthesis of cationic beta-vinyl substituted meso-tetraphenylporphyrins and their in vitro activity against herpes simplex virus type 1Publication . Silva, EMP; Giuntini, F; Faustino, MAF; Tome, JPC; Neves, MGPMS; Tome, AC; Silva, AMS; Santana-Marques, MG; Ferrer-Correia, AJ; Cavaleiro, JAS; Caeiro, MF; Duarte, RR; Tavares, SAP; Pegado, IN; d'Almeida, B; De Matos, APA; Valdeira, MLAn easy route to cationic beta-vinyl substituted meso-tetraphenylporphyrin derivatives is described. Two novel compounds were tested in vitro for their antiviral photoactivity against herpes simplex virus type 1. One of these compounds exhibited a significant activity, reaching 99% of virus inactivation after 15 min of photoactivation. (c) 2005 Elsevier Ltd. All rights reserved.
- Synthesis of glycoporphyrin derivatives and their antiviral activity against herpes simplex virus types 1 and 2Publication . Tome, JPC; Neves, MGPMS; Tome, AC; Cavaleiro, JAS; Mendonca, AF; Pegado, LSN; Duarte, R; Valdeira, MLStudies on the synthesis, structural elucidation, and antiviral evaluation of several carbohydrate-substituted meso-tetra-arylporphyrins against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are described. The potential of those photosensitizers, and of their precursors, on the photoinactivation of HSV-1 and HSV-2 was examined in Vero cells. Their virucidal and viral replication effects were assessed under white light, at their maximum noncytotoxic concentrations. The highest inhibitory effects on viral replication, for both viruses, were obtained with the glycoporphyrins where the sugar moiety bears unprotected hydroxyl groups. Strong inhibition of virus yield was observed even at concentrations much lower than their maximum noncytotoxic concentrations. These compounds can be postulated to be useful as potential drugs for the treatment of herpes simplex viruses infections. (c) 2005 Elsevier Ltd. All rights reserved.