Browsing by Author "Torres, Isabel"
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- Impacto dos fatores psicossociais de risco na qualidade de vida da população no processo de reformaPublication . Gaspar, Tania; Gómez-Baya, Diego; Torres, Isabel; Cerqueira, Ana; Correia, Manuela Faia; Matos, Margarida Gaspar deThe main objective ofthis study is to better understand and characterize the relationship between work-related psychosocial risk factors and quality of life dimensions in working and retired population. The data were collected at national level in Portugal. Participants were 1,330 persons, 62.2% of which female, with ages ranging between 55 and 75 years old. Were analyzed gender, age and professional status (professional active and retired) differences in relation to psychosocial risk factors and quality of life. Five regressions models were tested. Results showed that the stress/burnout management and work overload are the psychosocial risk factors that presented a strong impact in quality of live. Quality of live dimensions. Our study allowed to conclude that quality of life in retirement and aging process is influenced by work-related psychosocial risks, especially stress management and work overload.
- Oyster shells’ incorporation into mortar to achieve blue circular economy: LCA case study in PortugalPublication . Bellei, Poliana; Schäfer, Giovanna; Magalhães, Fernanda; Torres, Isabel; Marques da Costa, Eduarda; Solstad, Runar; Flores-Colen, InêsCurrently, society's great challenge is to face climate change and mitigate environmental impacts. This study aims to identify the environmental impacts of recovering traditional construction techniques in coastal regions by incorporating oyster shells into mortar to achieve the objectives of the blue circular economy. The possible environmental impacts are measured using Life Cycle Assessment. Oyster shell is considered as a powder or an aggregate in construction, and comparison is made between mortars produced with percentages of substitutions of traditional materials by oyster shell incorporation. The case study was carried out in the Algarve region, in the south of Portugal. Consequently, the potential of circularity for a biomaterial derived from the aquaculture industry and its inclusion in different particle size in the construction industry is discussed. This work is part of the activities to be carried out within the scope of the EEA granted Shellter Project, which aims to explore the potential of incorporation of oyster shells in the production of construction materials within a circular economy model.
- Surveillance of succinate dehydrogenase gene mutation carriers : insights from a nationwide cohortPublication . Martins, Raquel; Cunha, Nuno; Simões, Helder; Matos, Maria João; Silva, João; Torres, Isabel; Rodrigues, Fernando; Leite, Valeriano; Teixeira, Manuel R.; Bugalho, Maria JoãoObjective: Mutations in the genes coding for succinate dehydrogenase (SDHx) are the most frequent germline alterations in pheochromocytomas and paragangliomas. Evidence for the advantages associated with presymptomatic screening for SDHx mutation carriers is scarce. This study describes a nationwide cohort of these mutation carriers and aims to compare patients with clinical manifestations of the disease and those diagnosed through genetic screening. Design: Cross-sectional study. Patients: SDHx mutation carriers (n = 118) followed through the Portuguese Oncology referral centres: 41 probands and 77 nonprobands. Measurements: All participants were subjected to biochemical and body imaging examinations for a complete assessment of the extent and spread of disease. Clinical data obtained this way were further analysed. Results: The mean age of this cohort was 44.5 ± 17.4 years, and more than half carried the same founder SDHB mutation. About 50.8% of the mutation carriers developed pheochromocytomas or paragangliomas. Compared to patients diagnosed through genetic screening, those diagnosed clinically were characterized by larger tumours (P < .001), more frequent metastases (P = .024), were more frequently subjected to surgery (P = .011) and radiotherapy (P = .013), and had worse outcomes, such as macroscopic positive margins (P = .034). Persistent and/or unresectable disease and disease-related mortality were also more frequent in symptomatic patients compared to those diagnosed through genetic screening (P = .014). Conclusions: In this nationwide cohort study, a large proportion of mutation carriers were found to develop SDHx-related neoplasia. Genetic testing and subsequent follow-up resulted in the diagnosis of smaller and nonmetastatic tumours, fewer treatment procedures, fewer complications and greater number of disease-free patients.