Browsing by Author "Rybin, Vladimir"
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- cAMP synthesis and degradation by phagosomes regulate actin assembly and fusion eventsPublication . Kalamidas, Stefanos A.; Kuehnel, Mark P.; Peyron, Pascale; Rybin, Vladimir; Rauch, Susanne; Kotoulas, Othon B.; Houslay, Miles; Hemmings, Brian A.; Gutierrez, Maximiliano G.; Anes, Elsa; Griffiths, GarethWe showed recently that actin assembly by phagosomal membranes facilitates fusion with late endocytic organelles in macrophages. Moreover, lipids that induced phagosomal actin also stimulated this fusion process. In macrophages infected with pathogenic my
- Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumenPublication . Kuehnel, Mark. P.; Rybin, Vladimir; Anand, Paras K.; Anes, Elsa; Griffiths, GarethLatex bead phagosomes isolated from J774 macrophages polymerize actin. We show here that five lipids phosphatidylinositol-4-phosphate, phosphatidylinositol-(4,5)bisphosphate, sphingosine-1-phosphate (S1P), ceramide-1-phosphate and phosphatidic acid - stim. - Fundacao para a Ciencia e a tecnologia (FCT). - We would like to thank Sabrina Marion and Simi Antony for their technical support. We greatly appreciate the suggestions by Jens Reich and Thomas Dandekar. Thanks also to Christopher Bleck for preparing Fig. 4 and to Luis Mayorga, Sabrina Marion and Maxim