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Browsing by Author "Rodriguez, Benjamin"

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  • Further diterpenoids from Plectranthus ornatus and P-grandidentatus
    Publication . Rijo, Patricia; Gaspar-Marques, Cristina; Simoes, Maria F.; Jimeno, Maria L.; Rodriguez, Benjamin
    A new halimane diterpenoid and the previously known labdane rhinocerotinoic acid were isolated from Plectranthus ornatus Codd. In addition, a new monoacetyl derivative of the abietane coleon U was found among the constituents of Plectranthus grandidentatus Gurke. These diterpenes could be significant from both chemotaxonomic and biogenetic points of view. (c) 2006 Elsevier Ltd. All rights reserved.
    2007Journal article Metadata only Show more
  • Isopimarane diterpenoids from Aeollanthus rydingianus and their antimicrobial activity
    Publication . Rijo, Patricia; Simoes, Maria Fatima; Duarte, Aida; Rodriguez, Benjamin
    Four acyloxy-isopimarane derivatives along with two known isopimarane diterpenoids, the flavone cirsimaritin and the sterols P-sitosterol and stigmasterol were isolated from the aerial parts of Aeollanthus rydingianus. The structures of the compounds were established on the basis of spectroscopic analysis and chemical evidence. The isolated substances were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria and a yeast strain. 19-Acetoxy-7,15-isopimaradien-3 beta-ol and 7,15-isopimaradien-19-ol showed minimum inhibitory concentration (MIC) values of 3.90-15.62 mu g/ml for Staphylococcus aureus and of 7.81 mu g/ml for Enterococcus hirae. (C) 2009 Elsevier Ltd. All rights reserved.. - Portuguese "Fundacao para a Ciencia e a Tecnologia" [SFRH/BD/19250/2004]; Spanish "Comision Interministerial de Ciencia y Tecnologia" [CTQ2006-15279-C03-02]. - We are grateful to Ernst van Jaarsveld, horticulturist, Kirstenbosch National Botanic Gardens (South Africa), for providing cuttings of A. rydingianus, and to Teresa Vasconcelos, researcher LIS[ (Lisbon), for the growing of the plants. This work was supported by funds from the Portuguese "Fundacao para a Ciencia e a Tecnologia" (FCT-MCES, to iMed.UL and as PhD Grant No. SFRH/BD/19250/2004) and also from the Spanish "Comision Interministerial de Ciencia y Tecnologia" (CICYT, Grant No. CTQ2006-15279-C03-02).
    2009Journal article Metadata only Show more
  • Terpenoids and phenolics from Plectranthus strigosus, bioactivity screening
    Publication . Gaspar-Marques, Cristina; Simoes, M. Fatima; Valdeira, M. Luisa; Rodriguez, Benjamin
    Further studies on Plectranthus sp. (Lamiaceae) led to the isolation of terpenes and phenol esters from Plectranthus strigosus Benth. ent-16-Kauren-19-ol (1), ent-16-kauren-19-oic acid (2), xylopic acid (3), xylopinic acid (4), hinokiol (5), 4 beta,6 beta-dihydroxy-1 alpha,5 beta(H)-guai-9-ene (6) 4 beta,6 beta-dihydroxy-1 alpha,5 beta(H)-guai-10(14)-ene (7), mixtures of hexacosan-1,26-diol and octacosan-1,28-diol ferulate diesters (8), of esters from ferulic acid and fatty alcohols (9) and of esters from fatty acids and 2-(4-hydroxyphenyl)-ethanol (10) were for the first time isolated from this genus. Supplementary spectral data for 3,8 and parvifloron D (11) metabolites are also presented. A bioactivity study revealed herpetic inhibitory properties for (1) and (2), and antioxidant ability for (5) and (8) phenolic constituents.
    2008Journal article Metadata only Show more