Browsing by Author "Gutierrez, Maximiliano Gabriel"
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- NF-kappa B activation controls phagolysosome fusion-mediated killing of mycobacteria by macrophagesPublication . Gutierrez, Maximiliano Gabriel; Mishra, Bibhuti B.; Jordao, Luisa; Elliott, Edith; Anes, Elsa; Griffiths, GarethMacrophages can potentially kill all mycobacteria by poorly understood mechanisms. In this study, we explore the role of NF-kappa B in the innate immune response of macrophages against Mycobacterium smegmatis, a nonpathogenic mycobacterium efficiently kil
- Role of lipids in killing mycobacteria by macrophagesPublication . Gutierrez, Maximiliano Gabriel; Gonzalez, Alexis Perez; Anes, Elsa; Griffiths, GarethWe have shown that several lipids can modulate the macrophage innate immune response against mycobacteria and enhance their killing. Since NF-kappa B is required for mycobacterial killing, we tested the ability of lipids to activate NF-kappa B in uninfect. - Alexander von Humboldt Foundation ; EMBO ; DFG [SPP-1267]; Fundacao para a Ciencia e a tecnologia (FCT) [PPCDT/BIA-BCM/55327/2007]. - We are grateful to David Liebl for critical reading of this manuscript. We would also like to thank Stefan Terjung at the Advanced Light Microscopy Facility and Andy Riddell at the Flow Cytometry Facility (EMBL, Heidelberg) for excellent technical assista