Browsing by Author "Gicquel, Brigitte"
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- Effects of omega-3 and-6 fatty acids on Mycobacterium tuberculosis in macrophages and in micePublication . Jordao, Luisa; Lengeling, Andreas; Bordat, Yann; Boudou, Frederic; Gicquel, Brigitte; Neyrolles, Olivier; Becker, Pablo D.; Guzman, Carlos A.; Griffiths, Gareth; Anes, ElsaWe recently showed that treatment of macrophages prior to Mycobacterium tuberculosis infection with the pro-inflammatory omega-6 lipid, arachidonic acid (AA) enhanced bacterial killing whereas the anti - inflammatory, omega-3 lipid eicosapentaenoic acid (. - FCT ; FEDER [POCI/BIA-BCM/55327/2004, SFRWBD/14284/2003]. - We thank Cecilia Rodrigues, Maximilliano Gutierrez, Luis Mayorga and Sabrina Marion for their constructive support and discussion. This work was financed by FCT with co-participation of FEDER (POCI/BIA-BCM/55327/2004 and SFRWBD/14284/2003).
- Modification of the mycobacteriophage Ms6 attP core allows the integration of multiple vectors into different tRNA(ala) T-loops in slow- and fast-growing mycobacteriaPublication . Dos Vultos, Tiago; Mederle, Isabelle; Abadie, Valerie; Pimentel, Madalena; Moniz-Pereira, Jose; Gicquel, Brigitte; Reyrat, Jean-Marc; Winter, NathalieBackground: Mycobacteriophage Ms6 integrates into Mycobacterium smegmatis and M. bovis BCG chromosome at the 3' end of tRNA(ala) genes. Homologous recombination occurs between the phage attP core and the attB site located in the T-loop. Integration-profic