Browsing by Author "Fernandes, A."
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- ALTERATIONS IN NEURODEVELOPMENT OCCUR BY MODERATED LEVELS OF UNCONJUGATED BILIRUBIN AND INCREASE WHEN NEURONS ARE CO-CULTURED WITH ASTROCYTESPublication . Falcao, A.; Fernandes, A.; Silva, S. L.; Vaz, A. R.; Brito, M. A.; Henrique, D.; Silva, R. F.; Brites, D.
- BILIRUBIN-INDUCED CHANGES AT NEURONAL CYTOSKELETAL DYNAMICSPublication . Fernandes, A.; Coutinho, E.; Lanier, L. M.; Brites, D.
- Biological risks for neurological abnormalities associated with hyperbilirubinemiaPublication . Brites, D.; Fernandes, A.; Falcao, A. S.; Gordo, A. C.; Silva, R. F. M.; Brito, M. A.Unconjugated bilirubin (UCB) injury to glial cells leads to the secretion of glutamate and elicits a typical inflammatory response. Release of pro-inflammatory cytokines may influence gliogenesis and neurogenesis, and lead to deficits in learning and memo. - Fundacao para a Ciencia e a Tecnologia (FCT), Lisbon, Portugal. - The authors are grateful to the Fundacao para a Ciencia e a Tecnologia (FCT), Lisbon, Portugal, for their support.
- Exploring Multidrug resistance-associated Protein 1 (MRP1) expression during Neural Stem Cell Proliferation and Diferentiation, Nerve Cell Maturation and Neuro-Glia InteractionsPublication . Falcao, A.; Torrado, E.; Fernandes, A.; Abranches, E.; Bekman, E.; Brito, A.; Silva, R. F. M.; Henrique, D.; Brites, D.
- Implications of nitrosative stress in apoptotic cascades mediated by pro-inflammatory cytokines in immature neuronsPublication . Vaz, A. R.; Leitão Silva, S.; Barateiro, A.; Fernandes, A.; Falcão, A. S.; Silva, R. F. M.; Brito, M. A.; Brites, D.The inflammatory response is essential for survival in response to tissue injury or infection, but it can also cause neuronal damage [1]. In fact, pro-inflammatory cytokines, as well as nitric oxide (NO), are known as mediators of neuronal apoptosis [2,3]. Although apoptosis occurs physiologically in the brain during the period of the growth spurt, an increase in the number of neurons undergoing apoptosis may produce neuropathological sequelae [4]. Therefore, the aim of the present study was to: (i) deepen characterize the mechanisms of neuronal apoptosis upon cytokine exposure in neuronal immature cells; and (ii) investigate the role of NO as a determinant.
- Influence of two nitrification inhibitors (DCD and DMPP) on annual ryegrass yield and soil mineral N dynamics after incorporation with cattle slurryPublication . Fangueiro, D.; Fernandes, A.; Coutinho, J.; Moreira, N.; Trindade, H.Nitrogen (N) losses through nitrate leaching, occurring after slurry spreading, can be reduced by the use of nitrification inhibitors (NIs) such as dicyandiamide (DCD) and 3,4-dimethyl pyrazole phosphate (DMPP). In the present work, the effects of DCD and DMPP, applied at two rates with cattle slurry, on soil mineral N profiles, annual ryegrass yield, and N uptake were compared under similar pedoclimatic conditions. Both NIs delayed the nitrate formation in soil; however, DMPP ensured that the soil mineral N was predominantly in the ammonium form rather than in the nitrate form for about 100 days, whereas with DCD such effect was observed only during the first 40 days after sowing. Furthermore, the use of NIs led to an increase of the drymatter (DM) yields in a range of 32–54% and of the forage N removal in a range of 34–68% relative to the slurry-only (SO) treatment (without NIs). A DM yield of 8698 kg ha21 was obtained with the DMPP applied at the greater rate against only 7444 kg ha21 obtained with the greater rate of DCD (4767 kg ha21 in the SO treatment). Therefore, it can be concluded that DMPP is more efficient as an NI than DCD when combined with cattle slurry
- Inhibition of nitric oxide production prevents apoptotic features mediated by inflammation in immature neuronsPublication . Vaz, A. R.; Silva, S. Leitao; Barateiro, A.; Fernandes, A.; Falcao, A. S.; Silva, R. F. M.; Brito, M. A.; Brites, D.
- Microglia acquires a phagocytic or pro-inflammatory phenotype when bilirubin gets into the brainPublication . Leitão Silva, S.; Osório, C.; Vaz, A. R.; Barateiro, A.; Falcão, A. S.; Brito, M. A.; Fernandes, A.; Silva, R. F. M.; Brites, D.
- NF-kappa B and apoptosis in colorectal tumourigenesisPublication . Aranha, M. M.; Borralho, P. M.; Ravasco, P.; da Silva, I. B. Moreira; Correia, L.; Fernandes, A.; Camilo, M. E.; Rodrigues, C. M. P.Background Nuclear factor-kappa B (NF-kappa B) may play an important role in colorectal tumourigenesis, controlling cell cycle and apoptosis gene expression. In addition, imbalances between cell proliferation and cell death are thought to underlie neoplas
- Nitric Oxide mediates Inflammation-Induced Apoptotic Features and Neuronal Dysfunction at an early stage of NeurodevelopmentPublication . Vaz, A. R.; Silva, Leitao S.; Barateiro, A.; Falcao, A. S.; Fernandes, A.; Silva, R. F. M.; Brito, M. A.; Brites, D.