Browsing by Author "Falcão, A. S."
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- Implications of nitrosative stress in apoptotic cascades mediated by pro-inflammatory cytokines in immature neuronsPublication . Vaz, A. R.; Leitão Silva, S.; Barateiro, A.; Fernandes, A.; Falcão, A. S.; Silva, R. F. M.; Brito, M. A.; Brites, D.The inflammatory response is essential for survival in response to tissue injury or infection, but it can also cause neuronal damage [1]. In fact, pro-inflammatory cytokines, as well as nitric oxide (NO), are known as mediators of neuronal apoptosis [2,3]. Although apoptosis occurs physiologically in the brain during the period of the growth spurt, an increase in the number of neurons undergoing apoptosis may produce neuropathological sequelae [4]. Therefore, the aim of the present study was to: (i) deepen characterize the mechanisms of neuronal apoptosis upon cytokine exposure in neuronal immature cells; and (ii) investigate the role of NO as a determinant.
- Microglia acquires a phagocytic or pro-inflammatory phenotype when bilirubin gets into the brainPublication . Leitão Silva, S.; Osório, C.; Vaz, A. R.; Barateiro, A.; Falcão, A. S.; Brito, M. A.; Fernandes, A.; Silva, R. F. M.; Brites, D.