Browsing by Author "Cristina, Filipa"
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- Antiretroviral Drug Resistance Surveillance among Treatment-Naive Human Immunodeficiency Virus Type 1-Infected Individuals in AngolaPublication . Bartolo, Ines; Rocha, Cheila; Bartolomeu, Jose; Gama, Antonio; Fonseca, Marlene; Mendes, Ana; Cristina, Filipa; Thamm, Sven; Epalanga, Marta; Silva, Patricia Cavaco; Taveira, NunoThe prevalence of transmitted human immunodeficiency virus type 1 drug resistance in Angola in 2001 in 196 untreated patients was investigated. All subtypes were detected, along with unclassifiable and complex recombinant strains. Numerous new polymorphis. - Fundacao GlaxoSmithKline das Ciencias da Saude and Fundacao para a Ciencia e Tecnologia, Portugal [PTDC/SAU-FCF/67673/2006]; Fundacao para a Ciencia e Tecnologia, Portugal. - This work was supported by grants from Fundacao GlaxoSmithKline das Ciencias da Saude and Fundacao para a Ciencia e Tecnologia, Portugal (PTDC/SAU-FCF/67673/2006). Ines Bartolo and Cheila Rocha are supported by Ph. D. grants from Fundacao para a Ciencia e
- Antiretroviral drug resistance surveillance among treatment-naive human immunodeficiency virus type 1-infected individuals in Angola: Evidence for low level of transmitted drug resistancePublication . Bártolo, Inês; Rocha, Cheila; Bartolomeu, José; Gama, António; Fonseca, Marlene; Mendes, Ana; Cristina, Filipa; Thamm, Sven; Epalanga, Marta; Silva, Patrícia Cavaco; Taveira, NunoThe prevalence of transmitted human immunodeficiency virus type 1 drug resistance in Angola in 2001 in 196 untreated patients was investigated. All subtypes were detected, along with unclassifiable and complex recombinant strains. Numerous new polymorphisms were identified in the reverse transcriptase and protease. Two (1.6%) unrelated patients harbored nucleoside reverse transcriptase inhibitor- and nonnucleoside reverse transcriptase inhibitor-resistant viruses (mutations: M41L, D67N, M184V, L210W, T215Y or T215F, and K103N). Continued surveillance of drug resistance is required for maximization of ART efficacy in Angola.