Gomes-Rocha, Sofia RaquelCosta-Pinho, André ManuelPais-Neto, Carolina Coelhode Araújo Pereira, AndréNogueiro, Jorge Pedro MartinsCarneiro, Silvestre Porfírio RamosSantos-Sousa, Hugo Miguel Teixeira FerrazLima-da-Costa, Eduardo JorgeBouça-Machado, RaquelPreto, John Rodrigues2021-10-182021-10-182021Obes Surg. 2021 Oct 120960-8923http://hdl.handle.net/10451/49938© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021Laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG) are safe procedures that may present sub-optimal results in superobesity (SO). A meta-analysis was performed aiming to summarize the available evidence on weight loss (primary outcome) and comorbidities resolution of LRYGB and LSG in patients with SO (BMI ≥ 50 kg/m2). From the 16 included studies, 7 integrated the meta-analysis. LRYGB showed a significantly higher weight loss at 6 to 12-months, but not after 24 months and a higher dyslipidemia resolution at 12 months. When compared with LSG, LRYGB achieved better weight loss after 6 and 12 months and higher dyslipidemia resolution after 1 year. There were no significant differences for resolution of the other co-morbidities studied.engBariatric surgeryComorbidity resolutionLRYGBLSGLaparoscopic Roux-en-Y gastric bypassLaparoscopic sleeve gastrectomyMeta-analysisSuper obesityWeight lossjournal article10.1007/s11695-021-05745-81708-0428