Soares, IvâniaPereira Amaral, InêsCorreia, Madalena P.Filipe, Paulo2024-01-302024-01-302024Urol Case Rep. 2023 Dec 9:52:102637http://hdl.handle.net/10451/62294© 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)We presents an unique and significant case of Acute Generalized Exanthematous Pustulosis (AGEP) associated with the use of tadalafil, a phosphodiesterase type 5 inhibitor for erectile dysfunction. AGEP, typically linked to antibiotics and antiepileptics, had not been previously reported with tadaladil in the MEDLINE database. The case involved a 40-year-old male who developed an erythematous rash, fever and sterile pustules after starting tadalafil. A skin biopsy confirmed AGEP. Discontinuation of the drug and treatment with prednsiolone cleared the dermatosis. This case emphasizes the need for awareness among healthcare providers regarding this potential adverse reaction, considering the growing use of tadalafil.engAGEPCutaneous adverse reactionTadalafiljournal article10.1016/j.eucr.2023.1026372214-4420