Gabriel, André F.Costa, Marina C.Enguita, Francisco J.2022-09-072022-09-072020Int J Mol Sci. 2020 Jan 10;21(2):4561661-6596http://hdl.handle.net/10451/54354© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Non-coding regulatory RNAs are generated as a core output of the eukaryotic genomes, being essential players in cell biology. At the organism level, they are key functional actors in those tissues and organs with limited proliferation capabilities such as the heart. The role of regulatory networks mediated by non-coding RNAs in the pathophysiology of cardiovascular conditions is starting to be unveiled. However, a deeper knowledge of the functional interactions among the diverse non-coding RNA families and their phenotypic consequences is required. This review presents the current knowledge about the functional crosstalk between circRNAs and other biomolecules in the framework of the cardiovascular diseases.engRNA regulatory networksCardiovascular diseasescircRNAsmiRNAsnon-coding RNAjournal article10.3390/ijms210204561422-0067